[CCoE Notice] Department of Electrical and Computer Engineering Materials Engineering Program Center for Integrated Bio and Nano Systems March 6, 2020

[Knudsen, Rachel W]

***** Seminar *****
Department of Electrical and Computer Engineering
Materials Engineering Program
Center for Integrated Bio and Nano Systems
  March 6, 2020
10:30 a.m., Room: AH108
Integrative neural interface for brain disorders
Lu Luan
ECE & BioE | Neuroengineering Initiative
Rice University
Abstract: Brain functions and dysfunctions involve complex interactions between neural, vascular and other cellular activities in a dynamic and long-lasting manner. This vast complexity demands the ability to simultaneously resolve multifaceted brain activities at sufficient spatiotemporal resolution, and to longitudinally track their evolution over a long period of time. These requirements exceed the capability of any single neurotechnology. In this talk, I will discuss the development of the chronic multimodal neural interface that combines neural recording, imaging, and microstimulation, and the opportunities it enables in studying brain disorders. I will start with the development of ultraflexible nanoelectronics threads (NETs) for scar-free tissue integration and chronically stable intracortical neural recording, which also facilitated longitudinal optical imaging in the same brain regions. I will then demonstrate the ability to simultaneously resolve and longitudinally track hemodynamic and neural activities, and its application in a mouse model of stroke, from which we observe a substantial neurovascular uncoupling after injury. I will conclude with our on-going development of high-resolution, chronically-stable microstimulation, and the opportunities the integrative neural interface enables for detecting, understanding, and treating a broad spectrum of neurological and neurodegenerative disorders.
[cid:image003.png at 01D5F165.B3B06350]Short Bio: Dr. Luan was trained as an experimental physicist. She received her B. S. from the University of Science and Technology of China and then went to Stanford University to pursue her Ph. D. in Physics (2011). After three years at Harvard University as a postdoctoral fellow in the Physics department, she moved to UT Austin in 2014 and made the transition to neuroengineering while being a research scientist in the department of Physics. She joined the Department of Biomedical Engineering as a research assistant professor in Sep 2017. She moved to Rice University in Oct 2019 as an assistant professor in department of electrical and computer engineering and as part of the neuroengineering initiative.
Contact Prof. Cunjiang Yucyu13 at Central.UH.EDU<mailto:cyu13 at Central.UH.EDU> if you would like to meet with Prof.Luan.
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