[CCoE Notice] Dissertation Announcement: Bioengineering A Three-Dimensional Cardiac Left Ventricle

[Grayson, Audrey A]

Title: Bioengineering A Three-Dimensional Cardiac Left Ventricle 
(Please see attached flyer for more information)

By: Nikita Patel, In Partial Fulfilment of the Requirements for the Degree of Doctor of Philosophy

Date: Monday, 23rd March 2015
Time: 10:00am
Place: SERC, Second Floor, SmartBoard Room
Faculty, Students and the general public are invited
Advisor: Dr. Ravi K. Birla

Abstract:

Hypoplastic left heart syndrome is a congenital condition characterized by an
underdeveloped left ventricle. The current treatment options are surgery and/or heart
transplant. Current tissue engineering strategies focus on graft models. The development of
an engineered 3D cardiac left ventricle would provide a therapeutic option to overcome
current treatment limitations.

A series of five in vitro models were developed, in order to bioengineer a 3D cardiac left
ventricle. Initially, the ideal material platform was studied, to produce the acellular
ventricular extracellular matrix (AVEM) model. A synthetic model of the left ventricle
chamber was developed to emulate left ventricle geometry and architecture; the
Bioengineered Open Ventricle (BEOV) model. The BEOV model was optimized with using
the two-stage perfusion cultured ventricle (TPCV) model and the pulsatile flow conditioned
ventricle (PFCV) model. Finally, we developed a bioengineered trileaflet valve, to produce
the Bioengineered Complete Ventricle (BECV) model.

This thesis defense will review the development of the five bioengineered models, and
summarize the future of this work both in hypoplastic left heart syndrome and in the field of
tissue engineering.
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