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<p class="MsoNormal"><!--[if gte vml 1]><v:shapetype id="_x0000_t75" coordsize="21600,21600" o:spt="75" o:preferrelative="t" path="m@4@5l@4@11@9@11@9@5xe" filled="f" stroked="f">
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</v:shapetype><v:shape id="Picture_x0020_1" o:spid="_x0000_s1026" type="#_x0000_t75" style='position:absolute;margin-left:0;margin-top:0;width:222pt;height:222.75pt;z-index:-251658240;visibility:visible;mso-wrap-style:square;mso-wrap-distance-left:9pt;mso-wrap-distance-top:0;mso-wrap-distance-right:9pt;mso-wrap-distance-bottom:0;mso-position-horizontal:absolute;mso-position-horizontal-relative:text;mso-position-vertical:absolute;mso-position-vertical-relative:text'>
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</v:shape><![endif]--><![if !vml]><img width="296" height="297" style="width:3.0833in;height:3.0937in" src="cid:image001.png@01DB7321.A14F85E0" align="left" hspace="12" v:shapes="Picture_x0020_1"><![endif]><b><span style="font-size:14.0pt;color:red">Giorgio
Bonmassar, Ph.D. <o:p></o:p></span></b></p>
<p class="MsoNormal"><span style="font-size:14.0pt">Associate Professor, Radiology
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt">Harvard Medical School<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt">Director, Analog Brain Imaging Laboratory
<br>
The Athinoula A. Martinos Center for Biomedical Imaging at Massachusetts General Hospital<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt;color:red">Date </span>
<span style="font-size:14.0pt">Friday, February 7, 2024<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt;color:red">Time </span>
<span style="font-size:14.0pt">11:30 a.m. to 1:30 p.m. <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt;color:red">Location </span>
<span style="font-size:14.0pt">Melcher Hall, Room 180<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt;color:red">Title</span><span style="font-size:14.0pt">:
<i>Metamaterial Deep Brain Stimulation Electrodes for Safe Magnetic Resonance Imaging and the Pathway for an FDA Approval</i><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt;color:red"><br>
Abstract</span><span style="font-size:14.0pt">: Deep Brain Stimulation (DBS) leads are essential for treating neurological conditions like Parkinson's disease. Still, their limited compatibility with magnetic resonance imaging (MRI) restricts many patients
with intracranial implants from using advanced functional MRI diagnostics, a standard and widely used medical diagnostic tool. Our research aims to resolve this quandary by developing a novel method to fabricate microwires for DBS leads, ensuring their safety
with MRIs up to 3T (MRI conditional). Drawing inspiration from oceanic science, particularly the concept of clapotisstanding ocean wavesand the way caisson-type breakwaters with rubble-mound beams disrupt these waves, our technology employs a sharp interface
between two metal segments on a non-conductive substrate. This design interrupts radiofrequency-induced currents, effectively reducing electrode heating, specific absorption rate (SAR), and MRI artifacts.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt"> <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt">In my presentation, I will discuss the fabrication of metamaterial fibers at CNS, utilizing established techniques such as Ion Beam Physical Vapor Deposition (PVD) and Reactive Ion Etching (RIE). These fibers
represent an advanced nanoscale thin-film metamaterial technology designed for MRI cloaking, offering the significant advantage of not requiring additional space within the brain, as when using additional RF limiting current components (e.g., chokes). Additionally,
I will detail the regulatory steps we are taking toward obtaining an Investigational Device Exemption (IDE) from the Food and Drug Administration for a Class III implantable device. This technological development could significantly improve the diagnostic
capabilities of MRI for patients with DBS implants and propel the progress in Active Implantable Medical Devices (AIMDs). Furthermore, in my presentation, I will briefly introduce other ongoing research projects in the Abilab, including microscopic magnetic
stimulation (ėMS) and high-frequency transspinal magnetic stimulation (HF-TSMS). Unlike traditional electrical stimulation, ėMS offers the unique capability to activate specific neuronal elements based on the orientation of the applied magnetic fields. HF-TSMS
integrates the benefits of high-frequency neuromodulation, traditionally used in invasive spinal cord stimulation therapies, into a non-invasive platform targeting spinal structures. These technologies highlight the lab's commitment to advancing non-invasive
neuromodulation techniques to address critical neuroscience and clinical medicine challenges.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt;color:red">Bio</span><b><span style="font-size:14.0pt">:</span></b><span style="font-size:14.0pt"> Dr. Giorgio Bonmassar is an Associate Professor of Radiology at Harvard Medical School and the Director of
the Analog Brain Imaging (ABI) Laboratory at the Athinoula A. Martinos Center for Biomedical Imaging at Massachusetts General Hospital (MGH). He is a Division of Sleep Medicine Faculty member at Harvard Medical School. He is the Chair of the IEEE P2010 standard
(Recommended Practice for Neurofeedback Systems, now published). He completed his initial Ph.D. in Electrical Engineering at the University of Rome "La Sapienza" in 1989 and a second Ph.D. in Biomedical Engineering from Boston University in 1997. His career
includes roles as a Systems Engineer at Ericsson, a Research Fellow at Boston University and MGH, and an Instructor of Radiology at MGH before becoming an Assistant Professor in 2005 and later an Associate Professor in Radiology in 2017.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt"> <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt">Dr. Bonmassar has been a leading Principal Investigator on numerous grants from the National Institutes of Health and the Department of Defense. He led as a Principal Investigator in U01, RO1, R18, R21, RO3,
R43/44 (SBIR), Shared Instrumentation (S10), Brain Initiative (R01), DoD (ONR and CIMIT/Army), and Foundation (Whitaker, Focused Ultrasound Foundation, CIMT) grants. He has authored over 100 international journal papers in biomedical engineering. He is a member
of the IEEE, the International Society for Magnetic Resonance in Medicine, and the Alfa Eta Mu Beta Biomedical Engineering Research Society. His awards include a North American Treaty Organization Advanced Research Studies Award, a Whitaker Foundation Biomedical
Engineering Grant for Young Investigators, and the Academy for Radiology & Biomedical Imaging Research Distinguished Investigator Award in 2020.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt"> <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt">Dr. Bonmassar's significant contributions to bioelectromagnetic research include the development of MRI-invisible microelectrodes, detailed in a 2008 Science publication that explored sensory modulation in
monkeys. His 2019 Science paper demonstrated increased CSF flow during sleep using EEG-fMRI. His pioneering work designing and manufacturing MRI-safe microstrips for EEG and Deep Brain Stimulation has led to the significant advancement of MRI-compatible electrophysiology.
He is a co-founder of eMRI Systems LLP, a recent startup for developing electrophysiology systems for MRI. <o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
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