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<td style="direction: ltr;"><span style="letter-spacing: normal; font-family: Arial, sans-serif; font-size: 12pt; font-weight: 400; color: rgb(0, 0, 0);"><img alt="Dissertation Defense Announcement at the Cullen College of Engineering" width="600" height="174" style="width: 600px; height: 174px;" src="https://www.egr.uh.edu/sites/www.egr.uh.edu/files/enews/2022/images/thesis1.png"></span>
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<span style="letter-spacing: normal; font-family: Arial, sans-serif; font-size: 24px; color: rgb(200, 16, 46);"><b>A Visual Query-driven Search Engine for Brain Tissue Analysis</b></span></p>
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<div style="direction: ltr; line-height: 20px; margin-bottom: 5px;"><span style="letter-spacing: normal; font-family: Arial, sans-serif; font-size: 18px; color: rgb(0, 0, 0);"><b>Rachel W Mills</b></span></div>
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<span style="letter-spacing: normal; font-size: 14px; font-weight: 400; color: rgb(0, 0, 0);">December 4, 2023; 10:00 AM (CST)</span></p>
<p style="direction: ltr; line-height: 22px; margin: 0px 0px 5px;"><span style="letter-spacing: normal; font-family: Arial, Helvetica, sans-serif; font-size: 14px; font-weight: 400; color: rgb(0, 0, 0);">Zoom:
</span><span style="letter-spacing: normal; font-family: Arial, Helvetica, sans-serif; font-size: 14px; color: rgb(200, 16, 46);"><a href="https://urldefense.com/v3/__https://uh-edu-cougarnet.zoom.us/j/88110213389?pwd=UkdjZkNQT29zVVhCTjZrK0dRTEM4Zz09__;!!LkSTlj0I!HCTY78-NnuZ3ZfNJZKFUoPZ1R7Ptvi5eCvx-aeG2AoIXXdVrce4YDFTKvEcNj7BxAaNO7vf0HIe4Cvpo1dNMks66MVU$" id="OWA4c37d377-af38-7be7-75ce-b61bf321c0d9" class="x_fui-Link x____10kug0w x_f3rmtva x_f1ewtqcl x_fyind8e x_f1k6fduh x_f1w7gpdv x_fk6fouc x_fjoy568 x_figsok6 x_f1hu3pq6 x_f11qmguv x_f19f4twv x_f1tyq0we x_f1g0x7ka x_fhxju0i x_f1qch9an x_f1cnd47f x_fqv5qza x_f1vmzxwi x_f1o700av x_f13mvf36 x_f1cmlufx x_f9n3di6 x_f1ids18y x_f1tx3yz7 x_f1deo86v x_f1eh06m1 x_f1iescvh x_fhgqx19 x_f1olyrje x_f1p93eir x_f1nev41a x_f1h8hb77 x_f1lqvz6u x_f10aw75t x_fsle3fq x_f17ae5zn x_OWAAutoLink" title="https://uh-edu-cougarnet.zoom.us/j/88110213389?pwd=ukdjzknqt29zvvhctjzrk0drtem4zz09" data-auth="NotApplicable" style="margin-top: 0px; margin-bottom: 0px;" data-loopstyle="linkonly">https://uh-edu-cougarnet.zoom.us/j/88110213389?pwd=UkdjZkNQT29zVVhCTjZrK0dRTEM4Zz09</a></span></p>
<p style="direction: ltr; line-height: 22px; margin: 0px 0px 5px;"><span style="font-family: Arial, Helvetica, sans-serif; font-size: 10.5pt; color: rgb(0, 0, 0);">Meeting ID: 881 1021 3389<br>
Passcode: 927074</span></p>
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<span style="letter-spacing: normal; font-size: 14px; color: rgb(0, 0, 0);"><b>Committee Chair:</b></span></p>
<p style="direction: ltr; line-height: 22px; margin: 0px 0px 5px;"><span style="letter-spacing: normal; font-family: Arial, Helvetica, sans-serif; font-size: 10.5pt; line-height: 200%; color: rgb(0, 0, 0);">Badrinath Roysam</span><span style="letter-spacing: normal; font-family: Arial, Helvetica, sans-serif; font-size: 10.5pt; color: rgb(0, 0, 0);">,
Ph.D.</span></p>
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<span style="letter-spacing: normal; font-size: 14px; color: rgb(0, 0, 0);"><b>Committee Members:</b></span></p>
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<span style="letter-spacing: normal; font-size: 14px; font-weight: 400; color: rgb(0, 0, 0);">Saurabh Prasad, Ph.D. | David Mayerich, Ph.D. | Hien Nguyen, Ph.D. | Dragan Maric, Ph.D.</span></p>
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<span style="letter-spacing: normal;"><b>Abstract</b></span></p>
<p style="direction: ltr; line-height: 22px; margin: 15px 0px;"><span style="letter-spacing: normal; font-family: Arial, Helvetica, sans-serif; font-size: 10.5pt; color: rgb(0, 0, 0);">We present a versatile strategy for analyzing whole-slide multiplex IHC
scans of brain tissue, without the confines, limitations, and programming needs of conventional script-based methods, using an alternative strategy based on a visual search engine. The engine learns the cytoarchitectural characteristics of provided training
images without human effort or intervention. Next, it accepts visual queries indicating one or more cells, and/or multicellular tissue patches of interest, and retrieves a rank-ordered spatially mapped list of similar other cells or tissue patches based on
cell morphologies, protein expression patterns, cytoarchitecture, myeloarchitecture, or local microvasculature, as appropriate. Retrievals from multiple queries can be co-analyzed using intuitive set-theoretic operations to generate sophisticated analyses
that would ordinarily require complex programming. We envision a broad range of uses, e.g., identifying cell populations, discovering cellular/cytoarchitectural similarities and differences across brain regions, delineating brain regions, fitting/ refining/
building atlases, delineating cortical cell layers, and proofreading segmentation results.</span></p>
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<td style="direction: ltr;"><span style="letter-spacing: normal; font-family: Arial, sans-serif; font-size: 12pt; font-weight: 400; color: rgb(0, 0, 0);"><img alt="Engineered For What's Next" width="600" height="82" style="width: 600px; height: 82px;" src="https://www.egr.uh.edu/sites/www.egr.uh.edu/files/enews/2022/images/dissertation2.png"></span></td>
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