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<b><span style="font-size:18.0pt;color:#C8102E;mso-ligatures:none">Removal of Pulsation Artifact From Intra-Operatively Recorded Local Field Potentials Using Sparse Signal Processing</span></b><o:p></o:p></p>
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<b><span style="font-size:13.5pt;color:black;mso-ligatures:none">Chandra Prakash Swamy</span></b><o:p></o:p></p>
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<span style="font-size:10.5pt;font-family:"Arial",sans-serif;color:black;mso-ligatures:none">May 1, 2023; 10:00 AM - 11:00 AM (CST)<br>
Location: Rm350, TIMES, HBS1<br>
Zoom: </span><a href="https://urldefense.com/v3/__https://www.google.com/url?q=https:**Auh-edu-cougarnet.zoom.us*j*91548504307&sa=D&source=calendar&usd=2&usg=AOvVaw25ajJiDWTZUH-ZpKVP0zxI__;Ly8vLw!!LkSTlj0I!G2G07_gdG1Z93dg_1SFnQAkfasSELoJe0p2vHaGyMjdJLXr731uRQXYVSmOJ6Bc7ujJVN8--XHfcaCyNaRyE9oC3gRk$" target="_blank"><span style="font-size:10.5pt;font-family:Roboto;letter-spacing:.15pt;background:white">https://uh-edu-cougarnet.zoom.us/j/91548504307</span></a><o:p></o:p></p>
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<b><span style="font-size:10.5pt;font-family:"Arial",sans-serif;color:black;mso-ligatures:none">Committee Chair:</span></b><span style="font-size:10.5pt;font-family:"Arial",sans-serif;color:black;mso-ligatures:none"><br>
Nuri Firat Ince, Ph.D.</span><o:p></o:p></p>
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<b><span style="font-size:10.5pt;font-family:"Arial",sans-serif;color:black;mso-ligatures:none">Committee Members:</span></b><span style="font-size:10.5pt;font-family:"Arial",sans-serif;color:black;mso-ligatures:none"><br>
Joe Francis, Ph.D. | David Francis, Ph.D. | Ashwin Viswanathan, M.D. </span><o:p></o:p></p>
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<b><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#C8102E;mso-ligatures:none">Abstract</span></b><o:p></o:p></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:12.0pt;color:black">Neural recordings frequently get contaminated by ECG or pulsation artifacts. These large amplitude components can mask the neural patterns of interest and make the visual
inspection process difficult. The current study describes a sparse signal representation strategy that targets to denoise pulsation artifacts in local field potentials (LFPs) recorded intraoperatively.
</span><o:p></o:p></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:12.0pt;color:black">To estimate the morphology of the artifact, we first detect the QRS-peaks from the simultaneously recorded ECG trace as an anchor point. After the LFP data has been epoched
with respect to each beat, a pool of raw data segments of a specific length is generated. Using the K-singular value decomposition (K-SVD) algorithm, we constructed a data-specific dictionary to represent each contaminated LFP epoch in a sparse fashion. Since
LFP is aligned to each QRS complex and the background neural activity is uncorrelated to the anchor points, we assumed that constructed dictionary will be formed to represent the pulsation artifact mainly. In this scheme, we performed an orthogonal matching
pursuit to represent each LFP epoch as a linear combination of the dictionary atoms. The denoised LFP data is thus obtained by calculating the residual between the raw LFP and its approximation.
</span><o:p></o:p></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:12.0pt;color:black">We discuss and demonstrate a significant improvement in denoised data and compare the results with respect to principal component analysis (PCA). We noted that there
is a comparable change in the signal for visual inspection to observe various oscillating patterns in the alpha and beta bands. We also see a noticeable compression of signal strength in the lower frequency band (<13 Hz), which was masked by the pulsation
artifact. We also show the denoised data by using a global dictionary which was generated by leaving one subject out, where the results were not significantly different. We compare the reconstructed denoised LFP data across various methods by computing their
signal-to-noise ratio (SNR) for each epoch with respect to the average of its pool.</span><o:p></o:p></p>
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