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<b><span style="font-size:20.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:#222222">The Industrial Engineering Department</span></b><b><span style="font-size:16.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:#222222"></span></b></p>
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<b><span style="font-size:16.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:#222222"><span style="mso-spacerun:yes"> </span></span></b></p>
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<b><span style="font-size:16.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:#222222">Invites the Cullen College of Engineering</span></b></p>
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<b><span style="font-size:16.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:#222222">To the</span></b></p>
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<b><span style="font-size:16.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:#222222">PhD Dissertation Defense</span></b></p>
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<b><span style="font-size:16.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:#222222">Of</span></b></p>
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<b><span style="font-size:16.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:#222222">X</span></b><b><span style="font-size:16.0pt;
font-family:"Times New Roman",serif;color:#222222;mso-fareast-language:ZH-CN">uemin</span></b><b><span style="font-size:16.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:#222222">
Bai</span></b></p>
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<b><span style="font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman";
color:#222222"><o:p> </o:p></span></b></p>
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<b><span style="font-size:14.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:#222222">Linear Energy Transfer (LET) - Guided Optimization Incorporating Biological Effectiveness for Intensity-Modulated Proton Therapy
</span></b></p>
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<b><span style="font-size:14.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:#222222"><span style="mso-spacerun:yes"> </span></span></b><span style="font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman";
color:#222222"></span></p>
<p align="center" style="margin: 0in 0in 8pt; line-height: 107%; font-size: 11pt; font-family: Calibri, sans-serif;margin-bottom:0in;margin-bottom:.0001pt;
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<b><span style="font-size:12.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:#222222">Date: Tuesday, November 19, 2019</span></b><span style="font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman";
color:#222222"></span></p>
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text-align:center;line-height:normal;background:white">
<b><span style="font-size:12.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:#222222"><span style="mso-spacerun:yes"> </span></span></b><span style="font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman";
color:#222222"></span></p>
<p align="center" style="margin: 0in 0in 8pt; line-height: 107%; font-size: 11pt; font-family: Calibri, sans-serif;margin-bottom:0in;margin-bottom:.0001pt;
text-align:center;line-height:normal;background:white">
<b><span style="font-size:12.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:#222222">Location: Engineering Build 2</span></b><span style="font-size:12.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:#222222">,
Room<b> E214</b></span><span style="font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman";
color:#222222"></span></p>
<p align="center" style="margin: 0in 0in 8pt; line-height: 107%; font-size: 11pt; font-family: Calibri, sans-serif;margin-bottom:0in;margin-bottom:.0001pt;
text-align:center;line-height:normal;background:white">
<b><span style="font-size:12.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:#222222">Time:
</span></b><span style="font-size:12.0pt;
font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman";
color:#222222">2:00 am – 4:00 pm</span><span style="font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:#222222"></span></p>
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text-align:center;line-height:normal;background:white">
<b><span style="font-size:12.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:#222222"><span style="mso-spacerun:yes"> </span></span></b><span style="font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman";
color:#222222"></span></p>
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<b><span style="font-size:12.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:#222222">Committee Chair:</span></b><b><span style="font-size:12.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:#1F497D">
</span></b><span style="font-size:12.0pt;
font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman";
color:#222222">Dr. Gino Lim</span><span style="font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:#222222"></span></p>
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text-align:center;line-height:normal;background:white">
<b><span style="font-size:12.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:#222222"><span style="mso-spacerun:yes"> </span></span></b><span style="font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman";
color:#222222"></span></p>
<p align="center" style="margin: 0in 0in 8pt; line-height: 107%; font-size: 11pt; font-family: Calibri, sans-serif;margin-bottom:0in;margin-bottom:.0001pt;
text-align:center;line-height:normal;background:white">
<b><span style="font-size:12.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:#222222">Committee Members:</span></b><span style="font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman";
color:#222222"></span></p>
<p style="margin: 0in 0in 0.0001pt; text-align: center; font-size: 12pt; font-family: "Times New Roman", serif">
<a>Dr. Wenhua Cao, Dr. </a><span style="mso-bookmark:m_7832068857419092532__Toc134716"><span style="mso-fareast-font-family:Batang">Taewoo Lee</span>,
<span style="color:#202124">Dr. </span></span><span style="mso-bookmark:m_7832068857419092532__Toc134716"><span style="mso-fareast-font-family:Batang">Cunjiang Yu</span><span style="color:#202124">,
</span>Dr. </span><span style="mso-bookmark:m_7832068857419092532__Toc134716"><span lang="EN" style="color:#202124;mso-ansi-language:EN">Ying Lin</span></span></p>
<p align="center" style="margin: 0in 0in 8pt; line-height: 107%; font-size: 11pt; font-family: Calibri, sans-serif;margin-bottom:0in;margin-bottom:.0001pt;
text-align:center;line-height:normal">
<span style="mso-bookmark:m_7832068857419092532__Toc134716"><span lang="EN" style="font-size:12.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";mso-ansi-language:EN"><o:p> </o:p></span></span></p>
<p align="center" style="margin: 0in 0in 8pt; line-height: 107%; font-size: 11pt; font-family: Calibri, sans-serif;margin-top:24.0pt;margin-right:0in;
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<span style="mso-bookmark:m_7832068857419092532__Toc134716"><b><span style="font-size:14.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:#222222;mso-font-kerning:18.0pt">Abstract</span></b></span><span style="mso-bookmark:m_7832068857419092532__Toc134716"></span><b><span style="font-size:14.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:#2E74B5;mso-font-kerning:18.0pt"></span></b></p>
<p style="margin: 0in 0in 0.0001pt; text-align: justify; text-indent: 24pt; line-height: 200%; font-size: 12pt; font-family: "Times New Roman", serif;line-height:normal">
Relative biological effectiveness (RBE) is used to measure the biological effect of treatment plans in Intensity modulated proton therapy (IMPT). However, this approach is challenging because of considerable model uncertainties for clinical tissues. Therefore,
the primary goal of this dissertation research is to develop biological effectiveness incorporated optimization approaches to enhance understanding of the biological impact of IMPT in radiation therapy research.</p>
<p style="margin: 0in 0in 0.0001pt; text-align: justify; text-indent: 24pt; line-height: 200%; font-size: 12pt; font-family: "Times New Roman", serif;line-height:normal">
Our work considers LET as a physical surrogate of biological effect in treatment planning. By maximizing dose-averaged LET in the target and minimizing it on OARs, the method not only can produce satisfactory dose distributions but also achieve reduced LET
distributions in critical structures as well as an increased LET in the target volume. Then, we develop a new mathematical model to increase the biological effect in radioresistant tumors in such a way that a robust biological effect distribution can be achieved.
To accomplish this purpose, the sum of the differences between the highest and the lowest biological effect in each voxel, approximated by the product of dose and LET, is penalized. After that, we noticed that using LET as a surrogate will increase the model
complexity and ignore the difference between dose and LET distribution, which is a more fundamental property. A study focuses on the potential benefits of LET keeps going up after the physical dose Bragg Peak is come up with to improve the biological effect
performance. avoid high values of LET in critical structures located within or near the target and increase LET in the tumor area, without compromising the target coverage. In the final work, the impact of BAOpt on the biological effect in IMPT is investigated.</p>
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