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<a name="x__Hlk531252741" id="LPlnk593528" class="OWAAutoLink" previewremoved="true"><b><span style="font-size:14.0pt; line-height:200%; font-family:"Arial","sans-serif"; color:black">MS DEFENSE STUDENT: </span></b></a><span style="font-size:14.0pt; line-height:200%; font-family:"Arial","sans-serif"; color:black">Conrad
Hom</span><span style="font-size:12.0pt; line-height:200%; color:black"></span></p>
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<b><span style="font-size:14.0pt; line-height:200%; font-family:"Arial","sans-serif"; color:black">DATE: </span></b><span style="font-size:14.0pt; line-height:200%; font-family:"Arial","sans-serif"; color:black">Thursday, December 6, 2018</span><span style="font-size:12.0pt; line-height:200%; color:black"></span></p>
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<b><span style="font-size:14.0pt; line-height:200%; font-family:"Arial","sans-serif"; color:black">TIME: </span></b><span style="font-size:14.0pt; line-height:200%; font-family:"Arial","sans-serif"; color:black">1:30 PM</span><span style="font-size:12.0pt; line-height:200%; color:black"></span></p>
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<b><span style="font-size:14.0pt; line-height:200%; font-family:"Arial","sans-serif"; color:black">PLACE:</span></b><span style="font-size:14.0pt; line-height:200%; font-family:"Arial","sans-serif"; color:black"> Engineering Building 1, Room N-328</span><span style="font-size:12.0pt; line-height:200%; color:black"></span></p>
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<b><span style="font-size:14.0pt; line-height:200%; font-family:"Arial","sans-serif"; color:black">THESIS CHAIR: </span></b><span style="font-size:14.0pt; line-height:200%; font-family:"Arial","sans-serif"; color:black">Dr. Navin Varadarajan</span><span style="font-size:12.0pt; line-height:200%; color:black"></span></p>
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<b><span style="font-size:14.0pt; line-height:105%; font-family:"Arial","sans-serif"">Kinetics of T-cell Killing in Three Dimensional Tumor Spheroids</span></b></p>
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3-D tumor spheroids more closely resemble the tumor microenvironment than traditional 2-D cell cultures. Past cancer models have focused on the interactions of effectors and targets at either the 2-D or 3-D level, but not both. Understanding the differences
between effector cell and tumor cell interactions in 2-D versus 3-D will help shed light on the mechanisms that make tumor spheroids more resilient. Here, we employed TALL-104 cells and DAOY cells as an ideal model to study the kinetics of cancer cells and
effector cells at both the single cell level and at the 3-D. A Timing assay was run to gather information about rate constants and in conjunction, the same set of TALL-104 cells was added to DAOY spheroids and studied using the Incucyte system. Two different
3-D models were created and fitted to the experimental data. The rate constants were then compared between the 2-D and 3-D models.</span></p>
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