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<p class="x_MsoNormal" align="center" style="text-align:center"><img width="601" height="39" id="x__x0000_i1031" alt="Measuring Metabolism in Microbial Communities
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<p class="x_MsoNormal" align="center" style="text-align:center"><img width="487" height="132" id="x__x0000_i1030" alt="Maciek R Antoniewicz, Ph.D.
Centennial Professor of Chemical and Biom. Engineering
University of Delaware
Friday, September 7, 2018, 10:30 am
Room L2, Building D2
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Measuring intracellular fluxes by 13C metabolic flux analysis (13C-MFA) has become a key activity in metabolic engineering, biotechnology and medicine. Here, I will present new advances in 13C-MFA that have extended the scope of this technology to more complex biological systems. Specifically, I will demonstrate a new approach that we have developed for elucidating syntrophic interactions in microbial communities. Syntrophy (or cross-feeding) is the co-existence of two or more microbes whereby one feeds off the products of the other. To dissect such interactions in complex communities we have developed a multi-scale 13C-MFA modeling approach that allows us, for the first time, to quantify metabolic fluxes, metabolite cross-feeding, and population dynamics.
Overall, the methods we have developed have opened new areas of investigation, allowing us to dissect systems that are of significant importance to biology. More broadly, by better understanding coordinated relationships at the genetic, molecular, cellular, and systems levels we are generating new knowledge on microbial syntrophy that enables us to ensemble synergistic interactions in engineered microbial communities for applications in biotechnology and medicine.
Dr. Maciek R. Antoniewicz is the Centennial (Endowed) Full Professor of Chemical and Biomolecular Engineering at the University of Delaware. Dr. Antoniewicz earned his B.S. and M.S. degrees in Chemical Engineering from Delft University of Technology (2000), and his Ph.D. in Chemical Engineering from the Massachusetts Institute of Technology (2006). After graduating he performed post-doctoral research at DuPont Company. Dr. Antoniewicz started as an Assistant Professor in 2007 and was promoted to Associate Professor in 2013. In 2016, he was appointed as the Centennial (Endowed) Full Professor of Chemical and Biomolecular Engineering. Dr. Antoniewicz is an expert and a pioneer in the field of 13C-metabolic flux analysis (13C-MFA). He has received many international awards for his research, including the DuPont Young Professor Award (2008), the James E. Bailey Young Investigator Award in Metabolic Engineering (2008), the NSF CAREER Award (2011), and Biotechnology and Bioengineering Daniel I.C. Wang Award (2015). His current interests are in elucidating syntrophic interactions in microbial communities, analysis of compartment-specific fluxes in cancer cells, dynamic flux analysis, and metabolic engineering of microbes for enhanced utilization of renewable substrates and production of value-added chemicals.
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