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<p class="MsoNormal" align="center" style="margin-bottom:6.0pt;text-align:center;
line-height:18.0pt;mso-line-height-rule:exactly"><b><span style="font-size: 12.5pt; font-family: 'Times New Roman'; ">Master’s Thesis Defense Announcement <o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="margin-bottom:6.0pt;text-align:center;
line-height:18.0pt;mso-line-height-rule:exactly"><strong><span style="font-size: 12.5pt; ">Date:</span></strong><span class="apple-converted-space"><span style="font-size: 12.5pt; font-family: 'Times New Roman'; "> </span></span><span style="font-size: 12.5pt; font-family: 'Times New Roman'; color: rgb(34, 34, 34); ">August
05, 2016</span><span style="font-size: 12.5pt; font-family: 'Times New Roman'; "> <o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="margin-bottom:6.0pt;text-align:center;
line-height:18.0pt;mso-line-height-rule:exactly"><strong><span style="font-size: 12.5pt; ">Time:</span></strong><span class="apple-converted-space"><span style="font-size: 12.5pt; font-family: 'Times New Roman'; "> </span></span><span style="font-size: 12.5pt; font-family: 'Times New Roman'; color: rgb(34, 34, 34); ">10:00
am</span><span style="font-size: 12.5pt; font-family: 'Times New Roman'; "><o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="margin-bottom:6.0pt;text-align:center;
line-height:18.0pt;mso-line-height-rule:exactly"><span style="font-size: 12.5pt; font-family: 'Times New Roman'; "> <strong>Place:</strong><span class="apple-converted-space"> Industrial Engineering Conference Room (</span></span><span style="font-size: 12.5pt; font-family: 'Times New Roman'; ">Room E214)<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="margin-bottom:6.0pt;text-align:center;
line-height:18.0pt;mso-line-height-rule:exactly"><span style="font-size: 12.5pt; font-family: 'Times New Roman'; ">Candidate: Sanaz Karamimoghaddam<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="margin-bottom:6.0pt;text-align:center;
line-height:18.0pt;mso-line-height-rule:exactly"><span style="font-size: 12.5pt; font-family: 'Times New Roman'; ">Committee Members: Dr. Gino Lim (Advisor), Dr.
Wenhua Cao (Co-Advisor), Dr. J. R. Rao<o:p></o:p></span></p>
<p class="normalSA" style="margin-bottom:6.0pt;line-height:18.0pt;mso-line-height-rule:
exactly"><span style="font-size:12.5pt">Title:<o:p></o:p></span></p>
<p class="normalSA" style="margin-bottom:6.0pt;line-height:18.0pt;mso-line-height-rule:
exactly"><span style="font-size:12.5pt">Evaluation of variable Proton
Biological Effectiveness in Proton Therapy</span><o:p></o:p></p>
<p class="normalSA"><o:p> </o:p></p>
<p class="normalSA"><o:p> </o:p></p>
<p class="normalSA" align="left" style="text-align:left"><o:p> </o:p></p>
<p class="MsoNormal" align="center" style="text-align:center;line-height:normal"><b><span style="font-size: 14pt; font-family: 'Times New Roman'; ">Abstract<o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center;line-height:normal"><b><span style="font-size: 12pt; font-family: 'Times New Roman'; "> </span></b></p>
<p class="MsoNormal" style="margin-bottom:6.0pt;text-align:justify;line-height:
17.4pt;mso-line-height-rule:exactly"><span style="font-size: 12pt; font-family: 'Times New Roman'; ">Proton therapy for treating cancer patients has been evolved
to become a highly desired choice of radiation therapy due to the physical
characteristic of protons. Currently, the biologic effectiveness of protons relative
to photons is considered to be a constant ratio of 1.1. However, experiments
show that the RBE is higher in different portions in proton ranges. Since the
usage of a constant RBE is justified based on experiments conducted using older
methods of dose delivery, the re-evaluation of using a constant RBE and
proposing models for determining RBE values is necessary now that recent
experimental results, using new actively scanned beam delivery method, are
available and suggest deviations from conventional data. To suggest a method
for calculating RBE values, an experiment by Guan et al is chosen to derive
biologic response results with respect to proton beams. A widely used phenomenological
RBE model by Wilkens and Oeflke is chosen for comparison purposes. The proposed
RBE model is based on Wilkens and Oeflke model with revisions on tissue
parameters behavior vs. LET based on Guan et al results. Three RBE models
including the constant RBE, Wilkens' model and the suggested model based on
Guan’s experiment are compared for three brain cancer patient cases. The comparisons
are demonstrated using cumulative RBE weighted dose volume histograms. The
sensitivity of models to tissue parameter changes are also analyzed. The
suggested model shows escalated variable RBE weighted dose compared to constant
RBE weighted dose, and it is sensitive to RBE model parameters in all three
patient studies.<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="margin-bottom:0in;margin-bottom:.0001pt;
text-align:center;line-height:normal"><span style="font-size: 12pt; font-family: 'Times New Roman'; "> </span></p>
<!--EndFragment--></div><div><div><div lang="EN-US" link="blue" vlink="purple"><div class="WordSection1" style="page: WordSection1; "></div></div></div></div></body></html>