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<p class="MsoNormal" align="center" style="margin-bottom:0in;margin-bottom:.0001pt;
text-align:center;line-height:normal"><b><span style="font-family: 'Times New Roman'; ">Manipulation of Cell Behavior via Regulation
of Cellular Adhesive States Using <o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="margin-bottom:0in;margin-bottom:.0001pt;
text-align:center;line-height:normal"><b><span style="font-family: 'Times New Roman'; ">Nano- and Micropatterned Substrates<o:p></o:p></span></b></p>
<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:
justify;line-height:normal"><b><span style="font-family: 'Times New Roman'; "> </span></b></p>
<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:
justify;line-height:normal"><b><span style="font-family: 'Times New Roman'; "> </span></b></p>
<p class="MsoNormal" align="center" style="margin-bottom:0in;margin-bottom:.0001pt;
text-align:center;line-height:normal"><span style="font-family: 'Times New Roman'; ">John
H. Slater, Ph.D.<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="margin-bottom:0in;margin-bottom:.0001pt;
text-align:center;line-height:normal"><span style="font-family: 'Times New Roman'; ">Assistant
Professor<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="margin-bottom:0in;margin-bottom:.0001pt;
text-align:center;line-height:normal"><span style="font-family: 'Times New Roman'; ">University
of Delaware<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="margin-bottom:0in;margin-bottom:.0001pt;
text-align:center;line-height:normal"><span style="font-family: 'Times New Roman'; ">Department
of Biomedical Engineering<o:p></o:p></span></p>
<p class="BGKeywords" style="margin-bottom:0in;margin-bottom:.0001pt;text-indent:
.25in;line-height:normal"><span style="font-size: 11pt; font-family: 'Times New Roman'; "> </span></p>
<p class="BGKeywords" style="margin-bottom:0in;margin-bottom:.0001pt;text-indent:
.25in;line-height:normal"><b><span style="font-size: 11pt; font-family: 'Times New Roman'; "> </span></b></p>
<p class="BGKeywords" style="margin-bottom:0in;margin-bottom:.0001pt;text-indent:
.25in;line-height:normal"><span style="font-size: 11pt; font-family: 'Times New Roman'; "> </span></p>
<p class="BGKeywords" style="margin-bottom:0in;margin-bottom:.0001pt;text-indent:
.25in;line-height:normal"><span style="font-size: 11pt; font-family: 'Times New Roman'; "> </span></p>
<p class="BGKeywords" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:
normal"><b><span style="font-size: 11pt; font-family: 'Times New Roman'; ">Abstract<o:p></o:p></span></b></p>
<p class="BGKeywords" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:
normal"><span style="font-size: 11pt; font-family: 'Times New Roman'; ">The
implementation of surfaces presenting subcellular-sized patterns of extracellular
matrix (ECM) components that allow for direct control over adhesion site
organization (placement, growth, maturation) and dynamics could provide a
direct approach for modulating the extent of cytoskeletal tension generated by
cells and allow for precise control over adhesion-mediated signaling events. Toward
this goal, I have developed surface patterning strategies that allow for the
fabrication of (i) subcellular-sized patterns of ECM components that dictate
adhesion site placement, growth, and maturation, (ii) multifaceted surfaces
that present pattern arrays of multiple ECM components with each component
confined to its own array, and (iii) cell-derived, biomimetic pattern configurations
derived from images of user chosen cells of interest (COI). I have implemented
these structured materials to investigate the influence of (i) adhesion
maturation on cell dynamics and migration, (ii) ECM composition on differential
integrin ligation and directional migration, and (iii) cell-derived, biomietic
patterning on the ability to recapitulate the adhesive state and cytoskeletal
architecture of a COI. These structured materials provide new tools for basic
biological studies concerning adhesion-mediated signaling and potentially a
means for priming cells toward a chosen phenotype prior to use in cell-based
therapeutics. <o:p></o:p></span></p>
<p class="BGKeywords" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:
normal"><span style="font-size: 11pt; font-family: 'Times New Roman'; "> </span></p>
<p class="BGKeywords" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:
normal"><b><span style="font-size: 11pt; font-family: 'Times New Roman'; ">Bio<o:p></o:p></span></b></p>
<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:
justify;line-height:normal"><span style="font-family: 'Times New Roman'; ">Dr. Slater<b> </b></span><span style="font-family: 'Times New Roman'; ">received a Bachelor of Science in Mechanical Engineering
from the University of North Carolina at Charlotte in 2001 and a PhD in Biomedical
Engineering with a Graduate Portfolio Degree in Nanoscience and Nanotechnology from
the University of Texas at Austin in 2008. He was a Postdoctoral Fellow in the
Bioengineering Department at Rice University until 2012 and a Research
Scientist in the Biomedical Engineering Department at Duke University until
2013. He is currently an Assistant Professor in the Biomedical Engineering
Department at the University of Delaware. His research interests include
mechanobiology, microfluidics, biomimetic materials, and cell and tissue
engineering. <o:p></o:p></span></p>
<p class="BGKeywords" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:
normal"><span style="font-size: 11pt; font-family: 'Times New Roman'; "> </span></p>
<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:
justify;line-height:normal;mso-layout-grid-align:none;text-autospace:none"><span style="font-family: 'Times New Roman'; "> </span></p>
<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:
justify;line-height:normal;mso-layout-grid-align:none;text-autospace:none"><span style="font-family: 'Times New Roman'; "> </span></p>
<p class="BGKeywords" align="center" style="margin-bottom:0in;margin-bottom:.0001pt;
text-align:center;text-indent:.25in;line-height:normal"><b><span style="font-size: 18pt; font-family: 'Times New Roman'; ">12/23/2015
10-11 am, Eng. Bldg. 2 Rm. 312<o:p></o:p></span></b></p>
<p class="BGKeywords" align="center" style="margin-bottom:0in;margin-bottom:.0001pt;
text-align:center;text-indent:.25in;line-height:normal"><b><span style="font-size: 18pt; font-family: 'Times New Roman'; ">Host:
Prof. Wei-Chuan Shih<o:p></o:p></span></b></p>
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justify;line-height:normal;mso-layout-grid-align:none;text-autospace:none"><span style="font-family: 'Times New Roman'; "> </span></p>
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<!--EndFragment--></body></html>