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<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-family: 'Times New Roman'; ">INVESTIGATION OF
NEUROVASCULAR COUPLING WITH MULTIMODAL IMAGING SYSTEM: A FNIRS-EEG STUDY<o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-size: 14pt; font-family: 'Times New Roman'; "> </span></b></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-family: 'Times New Roman'; ">Hasan
Onur Keles<o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-family: 'Times New Roman'; "> </span></b></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-family: 'Times New Roman'; ">July
27<sup>th</sup> 2015<o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-family: 'Times New Roman'; ">Smartboard Room #2013, SERC
Building<o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-family: 'Times New Roman'; ">2:00 PM<o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-family: 'Times New Roman'; "> </span></b></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-family: 'Times New Roman'; ">Committee Chair: </span></b><span style="font-family: 'Times New Roman'; ">Dr.
Ahmet Omurtag<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-family: 'Times New Roman'; ">Committee Members:<o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-family: 'Times New Roman'; ">Dr. Yasemin Akay, </span><span style="font-family: 'Times New Roman'; ">Dr. Nuri Ince,<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-family: 'Times New Roman'; ">Dr. Sridhar
Madala, Dr. Ting Chen<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph;
mso-pagination:none;mso-layout-grid-align:none;text-autospace:none"><span style="font-family: 'Times New Roman'; "> </span></p>
<p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph;
mso-pagination:none;mso-layout-grid-align:none;text-autospace:none"><b><span style="font-family: 'Times New Roman'; ">ABSTRACT<o:p></o:p></span></b></p>
<p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph;
mso-pagination:none;mso-layout-grid-align:none;text-autospace:none"><b><span style="font-family: 'Times New Roman'; "> </span></b></p>
<p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph;
line-height:150%"><span style="font-family: 'Times New Roman'; ">Technological advances in functional neuroimaging
contributed to understanding of the neurovascular coupling in humans over the
years, however, the temporal and spatial relationship between large-scale
neural oscillations and hemodynamic changes is still not completely understood
during the different states and different disease states of the human cortex.
It is also still unclear that what type of large-scale neural oscillations that
mostly drive to the hemodynamic signal. </span><span style="font-family: 'Times New Roman'; ">There
has been a need for novel tools and methods in neuroimaging to study
neurovascular coupling. <span style="background:white">This thesis focused on the development of simultaneous Functional Near-Infrared
Spectroscopy and Electroencephalography system (simultaneous fNIRS+EEG) that
can be used for the investigation of neurovascular coupling over the whole
head. The simultaneous fNIRS+EEG system is then applied to the resting state
studies in healthy adult subjects. The results of these resting state
experiments are presented. Our finding shows that the EEG signals at various
frequencies tend to drive hemoglobin concentration changes with a typical time
delay during the resting states. As side studies, the simultaneous fNIRS+EEG is
applied to the cognitive task and artifact experiments to evaluate the
suitability of the developed system. The results of these task and artifacts
experiments are also presented. Our goal was to characterize the basic
phenomena through practical, noninvasive methods in order to facilitate the
study of diseases known to affect neurovascular coupling, such as traumatic
brain injury. <o:p></o:p></span></span></p>
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