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<p align="center" style="text-align:center;background:white"><b><span style="font-size: 10.5pt; ">PhD Dissertation Announcement<o:p></o:p></span></b></p>
<p align="center" style="text-align:center;background:white"><b><span style="font-size: 10.5pt; ">DEVELOPMENT OF NANOSTRUCTURED MATERIALS
FOR DRUG DELIVERY AND TISSUE ENGINEERING <o:p></o:p></span></b></p>
<p align="center" style="text-align:center;background:white"><b><span style="font-size: 10.5pt; ">Iman Yazdi</span></b><span style="font-size: 10.5pt; font-family: Calibri; "><o:p></o:p></span></p>
<p align="center" style="text-align:center;background:white"><b><span style="font-size: 10.5pt; "> </span></b><span style="font-size: 10.5pt; font-family: Calibri; "><o:p></o:p></span></p>
<p align="center" style="text-align:center;background:white"><b><span style="font-size: 10.5pt; ">Defense Date:</span></b><span class="apple-converted-space"><span style="font-size: 10.5pt; "> </span></span><span style="font-size: 10.5pt; ">Friday, April 3<sup>rd</sup> 2015 <b>Time:<span class="apple-converted-space"> </span></b><span class="aqj">11:00 am</span><span class="apple-converted-space"> </span><b>Location Room:</b><span class="apple-converted-space"> </span>SERC 2<sup>nd</sup> Floor Smart Board Room
<o:p></o:p></span></p>
<p align="center" style="text-align:center;background:white"><b><span style="font-size: 10.5pt; ">Committee Chair: </span></b><span style="font-size: 10.5pt; ">Dr. Mauro
Ferrari and Dr. Metin Akay<o:p></o:p></span></p>
<p align="center" style="text-align:center;background:white"><b><span style="font-size: 10.5pt; ">Committee Members:</span></b><span class="apple-converted-space"><span style="font-size: 10.5pt; "> </span></span><span style="font-size: 10.5pt; ">Dr. Ennio Tasciotti, Dr. Ravi Birla, and
Dr. Yasemin Akay</span><span style="font-size: 10.5pt; font-family: Calibri; "><o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify;text-indent:.5in"><span style="font-family: 'Times New Roman'; "><br>
In the last decade many
classes of nanoscale materials have been developed to improve the delivery of
therapeutics to tissues and cells. The goal of this work was to rationally
design and engineer multifunctional nanomaterials with tunable properties to
control the release kinetics of therapeutic payloads. The work described herein
focuses on the development of materials with nanoscale features that allow them
to be environmentally responsive and to sustain release for long periods of
time in a controlled fashion. These materials enhance the pharmacological
property of the therapeutics by prolonging their half-life, improving drug
solubility and availability, and reducing cytotoxic side effects. All the
delivery platforms presented in this work were based on multistage mesoporous
silicon nanocarriers (MPS). <o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify;text-indent:.5in"><span style="font-family: 'Times New Roman'; ">Firstly, we showed that cefazolin loaded
MPS exhibited sustained bactericidal properties. Secondly, we described the
surface modification of these particles with natural hydrogel coatings to
enhance their ability to extend the release of cargo and preserve its
stability. Thirdly, we embedded MPS into a polymeric matrix to provide
long-term controlled release of growth factors for tissue engineering
applications. Fourthly, we combined all these approaches to engineer a hybrid
composite nanomaterial loaded with therapeutic molecules delivered via a
bioactive angiogenic hydrogel. This system released all molecules in a
sustained and controlled fashion while simultaneously promoting wound healing
and neovascularization. Finally, we developed and validated an injectable
nanostructured delivery system to provide an extended local anesthetic release
for the purpose of surgical analgesia using an incisional model of pain in
rodents. We demonstrated the controlled release of anesthetics from a
multilayered nanohydrogel and showed the homogeneous diffusion of the drugs at
the site of injection.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify;text-indent:.5in"><span style="font-family: 'Times New Roman'; ">The combination of different
nanostructured materials allowed us to build on the individual strengths of
each component and resulted in the development of drug delivery system with
tunable properties. These nanoscale materials were tested in the context of
different clinical domains: infection control, wound healing, pain management
and regenerative medicine. The results presented in my work provide fundamental
proof of the feasibility of these approaches in view of their translation to
the clinic. <o:p></o:p></span></p>
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