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mso-bidi-font-family:Calibri"><o:p></o:p></span></p><p class="MsoNormal" style="margin-top:.2pt"><span style="font-size:9.5pt;
mso-ascii-font-family:Calibri;mso-fareast-font-family:Calibri;mso-hansi-font-family:
Calibri;mso-bidi-font-family:Calibri"> </span></p><p class="MsoBodyText" style="margin-right:5.85pt"><span style="color:#222222">Recently<span style="letter-spacing:-.2pt"> </span><span style="letter-spacing:-.05pt">several</span><span style="letter-spacing:-.15pt"> </span><span style="letter-spacing:-.05pt">groups</span><span style="letter-spacing:-.15pt"> </span>have<span style="letter-spacing:-.15pt"> </span>been<span style="letter-spacing:-.15pt"> </span>able<span style="letter-spacing:-.15pt"> </span>to<span style="letter-spacing:-.1pt"> </span>decode<span style="letter-spacing:-.3pt"> </span><span style="letter-spacing:-.05pt">intentions</span><span style="letter-spacing:
-.15pt"> </span><span style="letter-spacing:-.05pt">directly</span><span style="letter-spacing:-.15pt"> </span>from<span style="letter-spacing:-.1pt"> </span>the<span style="letter-spacing:-.15pt"> </span>brain<span style="letter-spacing:2.55pt"></span>in<span style="letter-spacing:-.2pt"> </span>order<span style="letter-spacing:-.15pt"> </span>to<span style="letter-spacing:-.15pt"> </span>control<span style="letter-spacing:-.2pt"> </span>computer<span style="letter-spacing:-.15pt"></span>cursors<span style="letter-spacing:-.15pt"> </span>as<span style="letter-spacing:-.2pt"> </span>well<span style="letter-spacing:-.15pt"> </span>as<span style="letter-spacing:-.15pt"> </span>robotic<span style="letter-spacing:-.2pt"></span>arms<span style="letter-spacing:-.15pt"> </span>and<span style="letter-spacing:-.15pt"> </span>hands.<span style="letter-spacing:-.2pt"></span>Such systems<span style="letter-spacing:-.2pt"> </span>are<span style="letter-spacing:-.2pt"> </span>called<span style="letter-spacing:-.15pt"></span>brain<span style="letter-spacing:-.2pt"> </span>machine,<span style="letter-spacing:-.2pt"> </span>or<span style="letter-spacing:-.15pt"> </span>brain<span style="letter-spacing:-.2pt"> </span>computer<span style="letter-spacing:-.15pt"></span>interfaces<span style="letter-spacing:-.2pt"> </span>(BMI/BCI).<span style="letter-spacing:-.2pt"> </span>It<span style="letter-spacing:-.15pt"> </span>has
become<span style="letter-spacing:-.25pt"> </span>clear<span style="letter-spacing:
-.25pt"> </span>that<span style="letter-spacing:-.25pt"> </span>somatosensory<span style="letter-spacing:-.25pt"> </span>feedback<span style="letter-spacing:-.25pt"></span>from<span style="letter-spacing:-.25pt"> </span>such<span style="letter-spacing:-.25pt"> </span>neuroprosthetic<span style="letter-spacing:
-.25pt"> </span>limbs<span style="letter-spacing:-.25pt"> </span>to<span style="letter-spacing:-.25pt"> </span>the user<span style="letter-spacing:-.2pt"></span>should<span style="letter-spacing:-.15pt"> </span>allow<span style="letter-spacing:-.15pt"> </span>for<span style="letter-spacing:-.15pt"> </span>more<span style="letter-spacing:-.15pt"> </span>natural<span style="letter-spacing:-.15pt"></span>integration<span style="letter-spacing:-.2pt"> </span>with<span style="letter-spacing:-.15pt"> </span>the<span style="letter-spacing:-.15pt"> </span>user<span style="letter-spacing:-.15pt"> </span>and<span style="letter-spacing:-.15pt"> </span>help<span style="letter-spacing:-.15pt"> </span>make<span style="letter-spacing:-.2pt"> </span>such
systems<span style="letter-spacing:-.15pt"> </span>become<span style="letter-spacing:-.15pt"> </span>a<span style="letter-spacing:-.15pt"> </span>part<span style="letter-spacing:-.15pt"> </span>of<span style="letter-spacing:-.15pt"> </span>one<span style="letter-spacing:-.15pt"> </span>self,<span style="letter-spacing:-.15pt"></span>rather<span style="letter-spacing:-.15pt"> </span>than<span style="letter-spacing:-.15pt"> </span>being<span style="letter-spacing:-.15pt"></span>seen<span style="letter-spacing:-.15pt"> </span>as<span style="letter-spacing:-.15pt"> </span>a<span style="letter-spacing:-.15pt"> </span>tool,<span style="letter-spacing:-.15pt"> </span>or<span style="letter-spacing:-.15pt"> </span>attachment.
Over<span style="letter-spacing:-.2pt"> </span>the<span style="letter-spacing:
-.15pt"> </span>past<span style="letter-spacing:-.15pt"> </span>decade<span style="letter-spacing:-.2pt"> </span>my<span style="letter-spacing:-.15pt"> </span>lab<span style="letter-spacing:-.15pt"> </span>has<span style="letter-spacing:-.2pt"> </span>been<span style="letter-spacing:-.15pt"> </span>working<span style="letter-spacing:-.15pt"></span>on<span style="letter-spacing:-.15pt"> </span>both<span style="letter-spacing:-.2pt"> </span>the<span style="letter-spacing:-.15pt"> </span>movement<span style="letter-spacing:-.15pt"> </span>intention decoding<span style="letter-spacing:
-.35pt"> </span><span style="letter-spacing:-.05pt">and</span><span style="letter-spacing:-.25pt"> </span>sensory<span style="letter-spacing:-.3pt"></span>feedback<span style="letter-spacing:-.25pt"> </span>problems.<span style="letter-spacing:-.25pt"> </span>Recently<span style="letter-spacing:-.25pt"></span>we<span style="letter-spacing:-.3pt"> </span>have<span style="letter-spacing:
-.25pt"> </span>discovered<span style="letter-spacing:-.25pt"> </span>that<span style="letter-spacing:-.25pt"> </span>there<span style="letter-spacing:-.3pt"> </span>is<span style="letter-spacing:1.05pt"> </span>reward<span style="letter-spacing:-.25pt"></span>modulation<span style="letter-spacing:-.25pt"> </span>of<span style="letter-spacing:-.2pt"> </span>mirror<span style="letter-spacing:-.25pt"></span>like<span style="letter-spacing:-.25pt"> </span>neurons<span style="letter-spacing:-.2pt"> </span>in<span style="letter-spacing:-.25pt"> </span>the<span style="letter-spacing:-.2pt"> </span>primary<span style="letter-spacing:-.25pt"></span>sensorimotor<span style="letter-spacing:-.25pt"> </span>cortex,<span style="letter-spacing:-.2pt"> </span>and we<span style="letter-spacing:-.25pt"></span>have<span style="letter-spacing:-.2pt"> </span>coupled<span style="letter-spacing:-.2pt"> </span>this<span style="letter-spacing:-.25pt"> </span>information<span style="letter-spacing:-.2pt"> </span>with<span style="letter-spacing:-.2pt"> </span>a<span style="letter-spacing:-.25pt"> </span>reinforcement<span style="letter-spacing:
-.2pt"> </span>learning<span style="letter-spacing:-.2pt"> </span>(RL)<span style="letter-spacing:-.2pt"> </span>architecture<span style="letter-spacing:
-.25pt"> </span>to produce<span style="letter-spacing:-.2pt"> </span>an<span style="letter-spacing:-.15pt"> </span>autonomous<span style="letter-spacing:
-.2pt"> </span>BMI,<span style="letter-spacing:-.15pt"> </span>that<span style="letter-spacing:-.2pt"> </span>senses<span style="letter-spacing:-.15pt"></span>when<span style="letter-spacing:-.2pt"> </span>the<span style="letter-spacing:-.15pt"> </span>system<span style="letter-spacing:-.2pt"></span>either<span style="letter-spacing:-.15pt"> </span>needs<span style="letter-spacing:-.15pt"> </span>to<span style="letter-spacing:-.2pt"> </span>be
corrected<span style="letter-spacing:-.25pt"> </span>for<span style="letter-spacing:
-.25pt"> </span><span style="letter-spacing:-.05pt">future</span><span style="letter-spacing:-.25pt"> </span><span style="letter-spacing:-.05pt">use,</span><span style="letter-spacing:-.3pt"> </span><span style="letter-spacing:-.05pt">or</span><span style="letter-spacing:-.25pt"> </span><span style="letter-spacing:-.05pt">is</span><span style="letter-spacing:-.3pt"> </span><span style="letter-spacing:-.05pt">operating</span><span style="letter-spacing:-.2pt"> </span>as<span style="letter-spacing:-.2pt"> </span><span style="letter-spacing:-.05pt">the</span><span style="letter-spacing:-.25pt"> </span><span style="letter-spacing:-.05pt">individual</span><span style="letter-spacing:
-.25pt"> </span>would<span style="letter-spacing:-.2pt"> </span><span style="letter-spacing:-.05pt">like.</span><span style="letter-spacing:-.2pt"> </span>On<span style="letter-spacing:-.2pt"> </span><span style="letter-spacing:-.05pt">the</span><span style="letter-spacing:-.25pt"> </span>sensory<span style="letter-spacing:2.45pt;
mso-font-width:99%"> </span>feedback<span style="letter-spacing:-.2pt"> </span>side<span style="letter-spacing:-.2pt"> </span>of<span style="letter-spacing:-.2pt"> </span>the<span style="letter-spacing:-.2pt"> </span>BMI<span style="letter-spacing:-.2pt"> </span>we<span style="letter-spacing:-.2pt"> </span>have<span style="letter-spacing:-.2pt"> </span>utilized<span style="letter-spacing:-.2pt"> </span>model<span style="letter-spacing:-.2pt"> </span>predictive<span style="letter-spacing:-.2pt"> </span>control<span style="letter-spacing:-.2pt"></span>and microstimulation<span style="letter-spacing:-.2pt"> </span>of<span style="letter-spacing:-.2pt"> </span>the<span style="letter-spacing:-.2pt"> </span>sensory<span style="letter-spacing:-.2pt"> </span>thalamus<span style="letter-spacing:-.2pt"></span>to<span style="letter-spacing:-.2pt"> </span><span style="letter-spacing:
-.05pt">produce</span><span style="letter-spacing:-.2pt"> </span><span style="letter-spacing:-.05pt">natural</span><span style="letter-spacing:-.25pt"></span><span style="letter-spacing:-.05pt">like</span><span style="letter-spacing:
-.25pt"> </span><span style="letter-spacing:-.05pt">cortical</span><span style="letter-spacing:-.25pt"> </span>responses<span style="letter-spacing:
1.15pt;mso-font-width:99%"> </span>in<span style="letter-spacing:-.15pt"> </span>S1.<span style="letter-spacing:-.15pt"> </span>We<span style="letter-spacing:-.15pt"> </span>acomplished<span style="letter-spacing:-.15pt"> </span>this<span style="letter-spacing:-.15pt"> </span>by<span style="letter-spacing:-.15pt"> </span>generating<span style="letter-spacing:
-.15pt"> </span>template<span style="letter-spacing:-.15pt"> </span>S1<span style="letter-spacing:-.15pt"> </span>responses<span style="letter-spacing:
-.15pt"> </span>to<span style="letter-spacing:-.15pt"> </span>natural<span style="letter-spacing:-.1pt"> </span>touch<span style="letter-spacing:-.15pt"> </span>and
then<span style="letter-spacing:-.3pt"> </span>minimized<span style="letter-spacing:
-.25pt"> </span>the<span style="letter-spacing:-.25pt"> </span>difference<span style="letter-spacing:-.3pt"> </span>between<span style="letter-spacing:-.25pt"></span>our<span style="letter-spacing:-.25pt"> </span>prosthetically<span style="letter-spacing:-.25pt"> </span>induce<span style="letter-spacing:-.3pt"></span>S1<span style="letter-spacing:-.25pt"> </span>responses<span style="letter-spacing:-.25pt"> </span>and these<span style="letter-spacing:
-.2pt"> </span>templates.<span style="letter-spacing:-.15pt"> </span>I<span style="letter-spacing:-.2pt"> </span>will<span style="letter-spacing:-.15pt"> </span>introduce<span style="letter-spacing:-.2pt"> </span>and<span style="letter-spacing:-.15pt"> </span>discuss<span style="letter-spacing:-.15pt"> </span>both<span style="letter-spacing:-.2pt"> </span>of<span style="letter-spacing:-.15pt"> </span><span style="letter-spacing:-.05pt">these</span><span style="letter-spacing:-.2pt"> </span>sides<span style="letter-spacing:-.2pt"> </span>of<span style="letter-spacing:-.2pt"> </span>our<span style="letter-spacing:-.2pt"> </span><span style="letter-spacing:-.05pt">BMI</span><span style="letter-spacing:1.2pt"> </span>development.<span style="letter-spacing:-.05pt"> </span> </span><o:p></o:p></p><!--EndFragment--></body></html>