<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40"><head><META HTTP-EQUIV="Content-Type" CONTENT="text/html; charset=us-ascii"><meta name=Generator content="Microsoft Word 12 (filtered medium)"><!--[if !mso]><style>v\:* {behavior:url(#default#VML);}
o\:* {behavior:url(#default#VML);}
w\:* {behavior:url(#default#VML);}
.shape {behavior:url(#default#VML);}
</style><![endif]--><style><!--
/* Font Definitions */
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
@font-face
{font-family:Tahoma;
panose-1:2 11 6 4 3 5 4 4 2 4;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0in;
margin-bottom:.0001pt;
font-size:11.0pt;
font-family:"Calibri","sans-serif";}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:blue;
text-decoration:underline;}
a:visited, span.MsoHyperlinkFollowed
{mso-style-priority:99;
color:purple;
text-decoration:underline;}
p.MsoAcetate, li.MsoAcetate, div.MsoAcetate
{mso-style-priority:99;
mso-style-link:"Balloon Text Char";
margin:0in;
margin-bottom:.0001pt;
font-size:8.0pt;
font-family:"Tahoma","sans-serif";}
span.BalloonTextChar
{mso-style-name:"Balloon Text Char";
mso-style-priority:99;
mso-style-link:"Balloon Text";
font-family:"Tahoma","sans-serif";}
span.EmailStyle19
{mso-style-type:personal;
font-family:"Calibri","sans-serif";
color:windowtext;}
span.EmailStyle20
{mso-style-type:personal-reply;
font-family:"Calibri","sans-serif";
color:#1F497D;}
.MsoChpDefault
{mso-style-type:export-only;
font-size:10.0pt;}
@page WordSection1
{size:8.5in 11.0in;
margin:1.0in 1.0in 1.0in 1.0in;}
div.WordSection1
{page:WordSection1;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1026" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]--></head><body lang=EN-US link=blue vlink=purple><div class=WordSection1><div><p class=MsoNormal><span style='color:#1F497D'>CORRECTION: This seminar will take place at 11am in room SEC 104.</span><span style='color:#1F497D'><o:p></o:p></span></p></div><p class=MsoNormal><span style='color:#1F497D'><o:p> </o:p></span></p><div><div style='border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0in 0in 0in'><p class=MsoNormal><b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>From:</span></b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'> engi-dist-bounces@EGR.UH.edu [mailto:engi-dist-bounces@EGR.UH.edu] <b>On Behalf Of </b>Grayson, Audrey A<br><b>Sent:</b> Wednesday, January 29, 2014 11:09 AM<br><b>To:</b> engineering-student@listserv.uh.edu; engi-dist@egr.uh.edu<br><b>Subject:</b> [CCoE Notice] ECE Seminar on Monday: Photonic Crystal Enhanced Microscopy: A New Tool for Imaging Cell-Surface Interactions and High Sensitivity Biomolecule Detection<o:p></o:p></span></p></div></div><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal style='margin-bottom:12.0pt'><b>When: Monday, February 3<sup>rd</sup>, 11am<br>Where: SEC 104<br>For more information, please visit: <a href="http://www.ee.uh.edu/research/speaker-series">http://www.ee.uh.edu/research/speaker-series</a> <o:p></o:p></b></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal align=center style='text-align:center'><b>ECE SEMINAR: Photonic Crystal Enhanced Microscopy: <br>A New Tool for Imaging Cell-Surface Interactions and High Sensitivity Biomolecule Detection<o:p></o:p></b></p><p class=MsoNormal align=center style='text-align:center'><o:p> </o:p></p><p class=MsoNormal align=center style='text-align:center'>Prof. Brian T. Cunningham<o:p></o:p></p><p class=MsoNormal align=center style='text-align:center'>Department of Electrical & Computer Engineering, Department of Bioengineering<o:p></o:p></p><p class=MsoNormal align=center style='text-align:center'>University of Illinois at Urbana-Champaign<o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal>The processes by which cells interact with basement membranes of biological tissues are fundamental aspects of important processes that include stem cell differentiation, cancer cell metastasis, apoptosis, division, and chemotaxis. Existing tools such as bright field microscopy and fluorescence microscopy of stained cells, lack the ability to quantify and to image the strength of live cell membrane interactions with surfaces over extended time scales that are required for processes that occur over the course of hours or days. To address this need, our group recently introduced Photonic Crystal Enhanced Microscopy (PCEM), in which a conventional bright field microscope is modified to enable detection of the resonant wavelength of a photonic crystal (PC) biosensor surface with ~0.6 <span style='font-family:Symbol'>m</span>m spatial resolution. Using PCs coated with extracellular matrix material to mimic the surface experienced by live cells within tissue, cell-surface interactions can be visualized and quantified without the use of fluorescent tags or colored stains, enabling dynamic tracking of focal adhesions, cell-surface attachment boundary, and cell attachment gradients within individual cells.<o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal>Due to the high sensitivity afforded by PCEM, we have demonstrated the ability to detect and image the adsorption of individual dielectric and metallic nanoparticles, extending down to ~35 nm diameter. In this talk, we demonstrate that utilizing gold nanorod tags with surface plasmon resonances that match the resonant wavelength of the PC, the signal-to-noise ratio for nanoparticle detection is enhanced, offering a path to use PCEM as a platform for detection and monitoring of biomolecular interactions with single molecule resolution for applications that include high sensitivity disease diagnostics.<o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal>In this talk, Prof. Cunningham will describe the operation, design, and fabrication of photonic crystal biosensors, describe the operation of the PCEM, and share recent results in which PCEM has been applied to stem cell imaging, fluorescence enhancement, and single nanoparticle detection.<o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal>--------------<o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><a name="_GoBack"></a>Brian T. Cunningham is a Professor in the Department of Electrical and Computer Engineering and the Department of Bioengineering at the University of Illinois at Urbana-Champaign, where he also serves as the Interim Director of the Micro and Nanotechnology Laboratory, and as Director of the NSF Center Innovative Instrumentation Technology (CIIT). His research is in the development of biosensors and detection instruments for pharmaceutical high throughput screening, disease diagnostics, point-of-care testing, life science research, and environmental monitoring. He has published 125 peer-reviewed journal articles, and is an inventor on 75 issued US patents. Prior to joining the faculty of Illinois in 2004, Prof. Cunningham was a co-founder of SRU Biosystems in 2000. He founded Exalt Diagnostics in 2012 to commercialize photonic crystal enhanced fluorescence technology for disease biomarker detection. Acoustic MEMS biosensor technology that he developed in his early career at Draper Laboratory has been licensed and commercialized by Bioscale, Inc. for applications in pathogen detection and diagnostics. Prof Cunningham’s work has been recognized with the IEEE Sensors Council Technical Achievement Award for the invention, development, and commercialization of sensors based upon photonic crystals. He is a Fellow of IEEE, OSA, AIMBE, and is a member of the National Academy of Inventors. Additional information on his research can be found on his web site: <a href="http://nano.ece.illinois.edu">http://nano.ece.illinois.edu</a>.<o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><img border=0 width=162 height=205 id="Picture_x0020_2" src="cid:image001.jpg@01CF1CEB.82FC7870"><o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p></div></body></html>