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</o:shapelayout></xml><![endif]--></head><body lang=EN-US link=blue vlink=purple><div class=WordSection1><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal align=center style='margin-bottom:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;page-break-after:avoid'><b><span style='font-size:16.0pt;font-family:"Tahoma","sans-serif"'>PhD Dissertation Defense<o:p></o:p></span></b></p><p class=MsoNormal align=center style='margin-bottom:0in;margin-bottom:.0001pt;text-align:center;line-height:normal'><b><span style='font-family:"Tahoma","sans-serif"'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='margin-bottom:0in;margin-bottom:.0001pt;text-align:center;line-height:normal'><b><span style='font-size:14.0pt;font-family:"Tahoma","sans-serif"'>Design and Testing of a Linearly Actuated Pulsatile Pump for Ventricular Assist<o:p></o:p></span></b></p><p class=MsoNormal align=center style='margin-bottom:0in;margin-bottom:.0001pt;text-align:center;line-height:normal'><b><span style='font-size:14.0pt;font-family:"Tahoma","sans-serif"'><br>Holley Carole Love<o:p></o:p></span></b></p><p class=MsoNormal align=center style='margin-bottom:0in;margin-bottom:.0001pt;text-align:center;line-height:normal'><b><span style='font-size:13.0pt;font-family:"Tahoma","sans-serif"'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='margin-bottom:0in;margin-bottom:.0001pt;text-align:center;line-height:normal'><b><span style='font-size:12.0pt'>Date: Friday, April 19th, 2013<o:p></o:p></span></b></p><p class=MsoNormal align=center style='margin-bottom:0in;margin-bottom:.0001pt;text-align:center;line-height:normal'><b><span style='font-size:13.0pt;font-family:"Tahoma","sans-serif"'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='margin-bottom:0in;margin-bottom:.0001pt;text-align:center;line-height:normal'><b><span style='font-size:12.0pt'>Location:</span></b><span style='font-size:12.0pt'> Heat Transfer Conference Room, Engr Bldg 1 - N263<o:p></o:p></span></p><p class=MsoNormal align=center style='margin-bottom:0in;margin-bottom:.0001pt;text-align:center;line-height:normal'><b><span style='font-size:12.0pt'>Time: </span></b><span style='font-size:12.0pt'>2:30 pm<b> </b><o:p></o:p></span></p><p class=MsoNormal align=center style='margin-bottom:0in;margin-bottom:.0001pt;text-align:center;line-height:normal'><b><span style='font-size:13.0pt;font-family:"Tahoma","sans-serif"'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='margin-bottom:0in;margin-bottom:.0001pt;text-align:center;line-height:normal'><b><span style='font-size:12.0pt'>Committee Chair: </span></b><span style='font-size:12.0pt'>Dr. Stanley J. Kleis<o:p></o:p></span></p><p class=MsoNormal align=center style='margin-bottom:0in;margin-bottom:.0001pt;text-align:center;line-height:normal'><b><o:p> </o:p></b></p><p class=MsoNormal align=center style='margin-bottom:0in;margin-bottom:.0001pt;text-align:center;line-height:normal'><b><o:p> </o:p></b></p><p class=MsoNormal align=center style='margin-bottom:0in;margin-bottom:.0001pt;text-align:center;line-height:normal'><b>Committee Members: <o:p></o:p></b></p><p class=MsoNormal align=center style='margin-bottom:0in;margin-bottom:.0001pt;text-align:center;line-height:normal'>Dr. Dong Liu<o:p></o:p></p><p class=MsoNormal align=center style='margin-bottom:0in;margin-bottom:.0001pt;text-align:center;line-height:normal'>Dr. Ralph Metcalfe<o:p></o:p></p><p class=MsoNormal align=center style='margin-bottom:0in;margin-bottom:.0001pt;text-align:center;line-height:normal'>Dr. Keh-Han Wang<br>Dr. William Cohn, Baylor College of Medicine <o:p></o:p></p><p class=MsoNormal align=center style='margin-bottom:0in;margin-bottom:.0001pt;text-align:center;line-height:normal'><span style='color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal align=center style='margin-bottom:0in;margin-bottom:.0001pt;text-align:center;line-height:normal'><o:p> </o:p></p><p class=MsoNormal style='text-align:justify'><span style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif";color:#222222;background:white'>The prevalence of heart failure around the world has led clinicians and engineers to develop mechanical circulatory support systems. Most heart assist technology today is classified as continuous flow because blood is pumped in a steady stream. Though well tolerated in general, some patients experience complications that appear to stem from the loss of pulsation. To investigate the role of pulsatility, a linearly actuated pulsatile pump (LAPP) has been designed. Unlike early pulsatile devices that lacked robustness, the LAPP has a single translating part plus two prosthetic valves. To aid in the design process, numerical models were developed using the commercial software packages COMSOL and FLUENT. Bench-top testing loops were also developed. The LAPP has been shown to be capable of providing pulsatile flow at physiologically relevant pressures, and preliminary studies have been conducted to assess its damage to blood. A major outstanding concern is the excessive heat generation requiring external cooling in the present prototype. Despite the heating, the LAPP has potential to become a clinical research tool for studying pulsatility, if not as an approved ventricular assist device.<o:p></o:p></span></p><p class=MsoNormal style='margin-bottom:0in;margin-bottom:.0001pt;text-indent:.5in;line-height:normal'><span style='font-size:12.0pt'><o:p> </o:p></span></p><p class=MsoNormal style='margin-bottom:0in;margin-bottom:.0001pt;text-indent:.5in;line-height:normal'><span style='font-size:12.0pt'><o:p> </o:p></span></p><p class=MsoNormal style='margin-bottom:0in;margin-bottom:.0001pt;text-indent:.5in;line-height:normal'><span style='font-size:12.0pt'><o:p> </o:p></span></p><p class=MsoNormal style='margin-bottom:0in;margin-bottom:.0001pt;text-indent:.5in;line-height:normal'><span style='font-size:12.0pt'><o:p> </o:p></span></p><p class=MsoNormal style='margin-bottom:0in;margin-bottom:.0001pt;text-indent:.5in;line-height:normal'><span style='font-size:12.0pt'><o:p> </o:p></span></p><p class=MsoNormal style='margin-bottom:0in;margin-bottom:.0001pt;text-indent:.5in;line-height:normal'><span style='font-size:12.0pt'><o:p> </o:p></span></p></div></body></html>