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yes">SEMINAR<o:p></o:p></span></u></b></p><p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:
normal"><u><span style="font-size:20.0pt;font-family:"Book Antiqua";mso-no-proof:
yes"><o:p><span style="text-decoration:none"> </span></o:p></span></u></b></p><p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:
normal"><span style="font-size:18.0pt;font-family:"Book Antiqua";color:#454545;
background:white">Motor Learning and Modulation in Autism</span></b><b style="mso-bidi-font-weight:normal"><span style="font-size:18.0pt;font-family:
"Book Antiqua";mso-no-proof:yes"><o:p></o:p></span></b></p><p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:
normal"><span style="font-size:18.0pt;font-family:"Book Antiqua";mso-no-proof:
yes">Stewart Mostofsky<o:p></o:p></span></b></p><p class="MsoNormal" align="center" style="text-align:center"><i style="mso-bidi-font-style:
normal"><span style="font-size:16.0pt;font-family:"Book Antiqua";mso-bidi-font-family:
Arial;color:black;background:white">Center for Autism and Related Disorders<span class="apple-converted-space"> </span></span></i><i style="mso-bidi-font-style:
normal"><span style="font-size:16.0pt;font-family:"Book Antiqua";mso-no-proof:
yes"><o:p></o:p></span></i></p><p class="MsoNormal" align="center" style="text-align:center"><i style="mso-bidi-font-style:
normal"><span style="font-size:16.0pt;font-family:"Book Antiqua";mso-bidi-font-family:
"Lucida Grande";color:black">Johns Hopkins University</span></i><i style="mso-bidi-font-style:normal"><span style="font-size:16.0pt;font-family:
"Book Antiqua";mso-no-proof:yes"><o:p></o:p></span></i></p><p class="MsoNormal" align="center" style="text-align:center"><i style="mso-bidi-font-style:
normal"><span style="font-size:16.0pt;font-family:"Book Antiqua";mso-no-proof:
yes"><span style="mso-spacerun:yes"> </span><o:p></o:p></span></i></p><p class="MsoNormal" style="margin-left:-.5in;text-align:justify;text-justify:
inter-ideograph"><span style="font-family:"Book Antiqua";mso-bidi-font-family:
Arial;color:#454545;background:white">Internal action models refer to
sensory-motor programs that form the brain basis for a wide range of skilled
behavior and for understanding others’ actions. Development of these action
models, particularly those reliant on visual cues from the external world,
depends on connectivity between distant brain regions. Studies of children with
autism reveal anomalous patterns of motor learning and impaired execution of
skilled motor gestures. These findings robustly correlate with measures of
social and communicative function, suggesting that anomalous action model
formation may contribute to impaired development of social and communicative,
as well as motor, capacity in autism. <span class="apple-converted-space"> </span>Motor
signs can be measured with a high degree of precision and the neurologic basis
of motor function is well mapped out so that deviations observed in autism can
readily be understood at the brain level. <span class="apple-converted-space"> </span>This line of study can therefore lead
to important advances in understanding the neural basis of autism and, more
critically, can be used to guide effective therapies targeted at improving
social, communicative, and motor function. Evidence of, and the
theoretical basis for, an association in autism between motor skill impairments
and deficits in social and communicative skills will be presented. <span class="apple-converted-space"> </span>Convergent data from behavioral
neuroimaging techniques, revealing that autism-associated action model
formation may be related to abnormalities in neural connectivity, will also be
discussed.<span class="apple-converted-space"> </span> Finally, a basis
for apply these findings to advancing therapeutic intervention will be
presented.</span><span style="font-family:"Book Antiqua";mso-no-proof:yes"><o:p></o:p></span></p><p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph"><span style="font-size:11.0pt;font-family:"Book Antiqua";mso-no-proof:yes"><o:p> </o:p></span></p><p class="MsoNormal" style="margin-left:1.0in"><b style="mso-bidi-font-weight:
normal"><u><span style="font-size:14.0pt;font-family:"Book Antiqua";mso-no-proof:
yes">Date:</span></u></b><b style="mso-bidi-font-weight:normal"><span style="font-size:14.0pt;font-family:"Book Antiqua";mso-no-proof:yes"> Wednesday,
April 3, 2013<o:p></o:p></span></b></p><p class="MsoNormal" style="margin-left:1.0in"><b style="mso-bidi-font-weight:
normal"><u><span style="font-size:14.0pt;font-family:"Book Antiqua";mso-no-proof:
yes">Time:</span></u></b><b style="mso-bidi-font-weight:normal"><span style="font-size:14.0pt;font-family:"Book Antiqua";mso-no-proof:yes"> 5PM-6PM<o:p></o:p></span></b></p><p class="MsoNormal" style="margin-left:1.0in"><b style="mso-bidi-font-weight:
normal"><u><span style="font-size:14.0pt;font-family:"Book Antiqua";mso-no-proof:
yes">Location:</span></u></b><b style="mso-bidi-font-weight:normal"><span style="font-size:14.0pt;font-family:"Book Antiqua";mso-no-proof:yes"> CBB 120
(Classroom and Business Building)<o:p></o:p></span></b></p><p class="MsoNormal"><span style="font-size:14.0pt;font-family:"Book Antiqua""><o:p> </o:p></span></p><p class="MsoNormal" style="text-indent:-.5in"><span style="font-size:14.0pt;
font-family:"Book Antiqua"">For information, contact: Bhavin R. Sheth, <a href="mailto:brsheth@uh.edu">brsheth@uh.edu</a><b style="mso-bidi-font-weight:normal"><span style="mso-no-proof:yes"><o:p></o:p></span></b></span></p>
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