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</o:shapelayout></xml><![endif]--></head><body lang=EN-US link=blue vlink=purple><div class=WordSection1><p class=MsoNormal align=center style='text-align:center;line-height:110%'><b><span style='font-size:16.0pt;line-height:110%;color:red'>INDUSTRIAL ENGINEERING SEMINAR<o:p></o:p></span></b></p><p class=MsoNormal align=center style='text-align:center;line-height:110%'><b><span style='font-size:16.0pt;line-height:110%;color:red'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='text-align:center;line-height:110%'><b><span style='font-size:16.0pt;line-height:110%;color:red'>Date: March 29, 2013<o:p></o:p></span></b></p><p class=MsoNormal align=center style='text-align:center;line-height:110%'><b><span style='font-size:16.0pt;line-height:110%;color:red'>Time: 10am-11am<o:p></o:p></span></b></p><p class=MsoNormal align=center style='text-align:center;line-height:110%'><b><span style='font-size:16.0pt;line-height:110%;color:red'>Place: D 102<o:p></o:p></span></b></p><p class=MsoNormal align=center style='text-align:center;line-height:110%'><b><span style='color:navy'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='text-align:center;line-height:150%'><a name="_GoBack"></a><b><span style='font-size:14.0pt;line-height:150%'>Biased Sampling and Failure Time Data Analysis<o:p></o:p></span></b></p><p class=MsoNormal align=center style='text-align:center;line-height:150%'><b>By</b><b><span style='font-size:12.0pt;line-height:150%'><o:p></o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><b><o:p> </o:p></b></p><p class=MsoNormal align=center style='text-align:center'><b>Dr. Hao Liu<o:p></o:p></b></p><p class=MsoNormal align=center style='text-align:center'><b>Associate Professor of Biostatistics<o:p></o:p></b></p><p class=MsoNormal align=center style='text-align:center'><b>Dan L. Duncan Cancer Center and Department of Medicine <o:p></o:p></b></p><p class=MsoNormal align=center style='text-align:center'><b>Baylor College of Medicine<o:p></o:p></b></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal align=center style='text-align:center;line-height:110%'><b><span style='font-size:14.0pt;line-height:110%;color:red'>Abstract<o:p></o:p></span></b></p><p class=MsoNormal><span style='font-size:12.0pt'><o:p> </o:p></span></p><p class=MsoNormal style='text-align:justify'> When a recorded observation does not represent the distribution of the targeted population, biased sampling occurs and statistical methodology is required to correct the bias. Biased sampling has wide applications from astronomical survey, clinical trials, epidemiology study, financial performance, to industrial engineering. In this talk, we review the relevant statistical methods with the focus on the analysis of failure time data. By modeling a general sample selection mechanism parametrically, we show that the efficient semiparametric maximum likelihood estimation (MLE) can be achieved for the popular Cox model. We present a novel expectation and maximization (EM) algorithm to find the semiparametric MLE, which has considerable computational advantages. Finally, we demonstrate the proposed procedure with a real data analysis in an epidemiology study.<o:p></o:p></p><p class=MsoNormal style='text-align:justify'><o:p> </o:p></p><p class=MsoNormal align=center style='text-align:center;line-height:110%'><b><span style='font-size:14.0pt;line-height:110%;color:red'>Biography<o:p></o:p></span></b></p><p class=MsoNormal align=center style='text-align:center;line-height:110%'><b><span style='font-size:14.0pt;line-height:110%;color:red'><o:p> </o:p></span></b></p><p class=MsoPlainText style='text-align:justify'><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Dr. Hao Liu is an Associate Professor in Biostatistics at the Dan L. Duncan Cancer Center and Department of Medicine at Baylor College of Medicine. He received his undergraduate degree in Mathematics from Peking University in China, and a Master degree in Biostatistics from the University of California at Berkeley. Dr. Liu finished his doctoral study in Biostatistics at the University of Washington at Seattle. After a stint as an Assistant Professor at the University of California at Davis, he moved to Houston to joint Baylor College of Medicine. Dr. Liu has research interests on clinical trials as well as general statistical methodology.<o:p></o:p></span></p><p class=MsoNormal style='text-align:justify;line-height:110%'><b><span style='font-size:12.0pt;line-height:110%;font-family:"Times New Roman","serif";color:red'><o:p> </o:p></span></b></p><p class=MsoNormal><span style='color:#1F497D'><o:p> </o:p></span></p></div></body></html>