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</o:shapelayout></xml><![endif]--></head><body lang=EN-US link=blue vlink=purple><div class=WordSection1><h2>PhD Dissertation Defense Announcement<o:p></o:p></h2><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><b><span style='font-size:11.0pt;font-family:"Tahoma","sans-serif"'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><b><span style='font-size:12.0pt;font-family:"Tahoma","sans-serif"'>DEVELOPMENT OF PHASE STABILIZED SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY FOR BIOMEDICAL IMAGING AND ELASTOGRAPHY <o:p></o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><b><span style='font-size:14.0pt;font-family:"Tahoma","sans-serif"'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><b><span style='font-size:11.0pt;font-family:"Tahoma","sans-serif"'>Ravi Kiran Manapuram<o:p></o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><b><span style='font-size:11.0pt;font-family:"Tahoma","sans-serif"'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='text-align:center;line-height:200%'><b><span style='font-size:11.0pt;line-height:200%;font-family:"Tahoma","sans-serif"'>April 19, 2012, 1: 15 PM, N202-Mechanical Engineering Large conference<o:p></o:p></span></b></p><p class=MsoNormal align=center style='text-align:center;line-height:200%'><span style='font-size:11.0pt;line-height:200%;font-family:"Tahoma","sans-serif"'>Committee: Dr. Kirill Larin (Chair), Dr. Pradeep Sharma, Dr. Lowell Wood, Dr. Ralph Metcalfe, Dr. Matthew Franchek<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Tahoma","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal style='text-align:justify;line-height:150%'><span style='font-size:11.0pt;line-height:150%'>This dissertation describes the development and several applications of a system capable of noninvasive 3D imaging of tissues with near cellular resolution. This system is based on Optical Coherence Tomography (OCT) technique and can provide both imaging and phase sensitive measurements. The key characteristics of the developed system include: axial resolution of 8 µm, lateral resolution of 15 μm, imaging depth of 9 mm, signal-to-noise ratio of 101 dB and phase stability of 9 mrad (which translates to 1.9 nm of optical path length sensitivity). The system was applied to several biomedical applications such as detection of microbubbles in tissues and blood and assessing mechanical wave propagation under both <i>in vitro</i> and <i>in vivo </i>conditions<i>.</i> The results demonstrate capability of this technique to detect submicron air bubbles as well as measure amplitude (~ 30 nm) and speed of mechanical waves propagating on tissue surfaces. The high sensitivity of the system was exploited to measure microbubbles in mice tail vein and mechanical wave propagation in mice cornea as a function of age <i>in vivo</i>. To the best of our knowledge, this is the first time OCT is applied to assess microbubbles and mechanical wave parameters in ocular tissues <i>in vivo.</i> The results described in this dissertation provide necessary theoretical and experimental foundation for developing devices for future clinical applications. <o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Tahoma","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Tahoma","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'><o:p> </o:p></span></p></div></body></html>