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</o:shapelayout></xml><![endif]--></head><body lang=EN-US link=blue vlink=purple><div class=WordSection1><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal align=center style='mso-margin-top-alt:0in;margin-right:.4in;margin-bottom:0in;margin-left:.3in;margin-bottom:.0001pt;text-align:center'><b><i><span style='font-size:16.0pt;font-family:"Times New Roman","serif"'>Seminar<o:p></o:p></span></i></b></p><p class=MsoNormal align=center style='mso-margin-top-alt:0in;margin-right:.4in;margin-bottom:0in;margin-left:.3in;margin-bottom:.0001pt;text-align:center'><b><i><span style='font-size:16.0pt;font-family:"Times New Roman","serif"'>Monday, January 9th, 2012<o:p></o:p></span></i></b></p><p class=MsoNormal align=center style='mso-margin-top-alt:0in;margin-right:.4in;margin-bottom:0in;margin-left:.3in;margin-bottom:.0001pt;text-align:center'><b><i><span style='font-size:16.0pt;font-family:"Times New Roman","serif"'>12:00 PM – 1:00 PM<o:p></o:p></span></i></b></p><p class=MsoNormal align=center style='mso-margin-top-alt:0in;margin-right:.4in;margin-bottom:0in;margin-left:.3in;margin-bottom:.0001pt;text-align:center'><b><i><span style='font-size:16.0pt;font-family:"Times New Roman","serif"'>Engineering Building 2 Room E132 – Materials Lab<o:p></o:p></span></i></b></p><p class=MsoNormal style='margin-right:.4in'><span style='font-family:"Times New Roman","serif"'><o:p> </o:p></span></p><p class=MsoNormal align=center style='mso-margin-top-alt:0in;margin-right:.4in;margin-bottom:0in;margin-left:.3in;margin-bottom:.0001pt;text-align:center'><b><u><span style='font-size:16.0pt;font-family:"Times New Roman","serif"'>A multiphase porous media mechanics approach for tumor growth modeling<o:p></o:p></span></u></b></p><p class=MsoNormal align=center style='mso-margin-top-alt:0in;margin-right:.4in;margin-bottom:0in;margin-left:.3in;margin-bottom:.0001pt;text-align:center'><b><span style='font-family:"Times New Roman","serif"'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='mso-margin-top-alt:0in;margin-right:.4in;margin-bottom:0in;margin-left:.3in;margin-bottom:.0001pt;text-align:center'><b><span style='font-size:14.0pt;font-family:"Times New Roman","serif";color:#C00000'>Bernhard A. Schrefler<o:p></o:p></span></b></p><p class=MsoNormal align=center style='mso-margin-top-alt:0in;margin-right:.4in;margin-bottom:0in;margin-left:.3in;margin-bottom:.0001pt;text-align:center'><b><span style='font-family:"Times New Roman","serif"'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='mso-margin-top-alt:0in;margin-right:.4in;margin-bottom:0in;margin-left:.3in;margin-bottom:.0001pt;text-align:center'><span style='font-family:"Times New Roman","serif"'>Professor at the University of Padua and Senior Affiliate Member of The Methodist Hospital Research Institute, Department of Nanomedicine<o:p></o:p></span></p><p class=MsoNormal style='mso-margin-top-alt:0in;margin-right:.4in;margin-bottom:0in;margin-left:.3in;margin-bottom:.0001pt'><span style='font-family:"Times New Roman","serif"'><o:p> </o:p></span></p><p class=MsoNormal style='mso-margin-top-alt:0in;margin-right:.4in;margin-bottom:0in;margin-left:.3in;margin-bottom:.0001pt'><span style='font-family:"Times New Roman","serif"'>Multiphase porous media mechanics is used to model tumor growth. The governing equations are obtained by means of the Thermodynamically Constrained Averaging Theory (TCAT), rather than the less complete theory of mixture. This is a framework recently established <a name="_GoBack"></a>for the analysis of continua and porous media that is consistent over multiple scales. The multiphase porous media mechanics approach takes into account the interaction of more phases than legacy tumor growth models, which usually neglect the evolution of the interstitial fluid pressure. The tumor is first modeled as a multiphase system composed of an extracellular matrix, healthy cells, tumor cells which may become necrotic depending on the nutrient level and the pressure, and an interstitial fluid which transports nutrients. The governing equations are solved within a Finite Element framework for predicting the growth rate of the tumor mass and its individual components, as a function of the i) initial tumor-to-healthy cell density ratio; ii) nutrient concentration; and iii) mechanical strains. This seminar will discuss preliminary results of this model and of significant subsets of it. Application of this model to patient specific data will allow for patient-specific predictions of the optimal concentration of therapeutic agents.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'><o:p> </o:p></span></p><p class=MsoNormal style='mso-margin-top-alt:0in;margin-right:.3in;margin-bottom:0in;margin-left:.2in;margin-bottom:.0001pt;text-align:justify'><b><span style='font-family:"Times New Roman","serif"'>Professor Bernhard Schrefler</span></b><b><span lang=IT style='font-family:"Times New Roman","serif"'><o:p></o:p></span></b></p><p class=MsoNormal style='mso-margin-top-alt:0in;margin-right:.3in;margin-bottom:0in;margin-left:.2in;margin-bottom:.0001pt;text-align:justify'><b><span style='font-family:"Times New Roman","serif"'>Short Biography<o:p></o:p></span></b></p><p class=MsoNormal style='mso-margin-top-alt:0in;margin-right:.3in;margin-bottom:0in;margin-left:.2in;margin-bottom:.0001pt;text-align:justify'><b><span style='font-family:"Times New Roman","serif"'><o:p> </o:p></span></b></p><p class=MsoNormal style='mso-margin-top-alt:0in;margin-right:.3in;margin-bottom:0in;margin-left:.2in;margin-bottom:.0001pt;text-align:justify'><span style='font-family:"Times New Roman","serif"'>Professor Bernhard A. Schrefler received his Ph.D. in 1984 and D.Sc. in 1992 from the University of Wales, Swansea. He is on the Faculty of Engineering of the University of Padua since 1970, was promoted to Professor of Structural Design in 1980 and is Professor of Structural Mechanics from 1989 on. Dr. Schrefler is also a Senior Affiliate Member of The Methodist Hospital Research Institute in Houston, where he is affiliated with the Department of Nanomedicine. He was visiting Professor at the Ecole Centrale of Nantes, the University of Texas, Austin, the Ecole Polytechnique Federale of Lausanne, the Chuo University of Tokyo, the Ecole Normale Supérieure in Cachan, the Lodz University of Technology, at CNAM (Conservatoire National des Arts et Metiers), Paris, and Dalian University of Technology. Since 2001 he is secretary general of the International Centre of Mechanical Sciences (CISM) in Udine.<o:p></o:p></span></p><p class=MsoNormal style='mso-margin-top-alt:0in;margin-right:.3in;margin-bottom:0in;margin-left:.2in;margin-bottom:.0001pt;text-align:justify'><span style='font-family:"Times New Roman","serif"'>His current research focuses on tumor growth modeling and transport of nanoparticles in diseased microvasculature. Other research interests deal with multiphase porous media mechanics with applications to bioengineering and environmental engineering, multiphase models for young concrete and concrete at high temperatures with application to tunnel fires, leaching and Alkali-Aggregate reaction, use of Artificial Neural Networks as constitutive models, for parameter identification and optimization, and with design of superconducting coils for controlled nuclear fusion technology.<o:p></o:p></span></p><p class=MsoNormal style='mso-margin-top-alt:0in;margin-right:.3in;margin-bottom:0in;margin-left:.2in;margin-bottom:.0001pt;text-align:justify'><span style='font-family:"Times New Roman","serif"'>Professor Schrefler is co-author in more than 430 scientific publications and co-author/editor of 29 books. He is regional editor of Mechanics Research Communications and serves on the editorial board of 19 Journals. <o:p></o:p></span></p><p class=MsoNormal style='mso-margin-top-alt:0in;margin-right:28.35pt;margin-bottom:0in;margin-left:28.35pt;margin-bottom:.0001pt'><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'><o:p> </o:p></span></p><p class=MsoNormal style='mso-margin-top-alt:0in;margin-right:28.35pt;margin-bottom:0in;margin-left:28.35pt;margin-bottom:.0001pt'><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'><o:p> </o:p></span></p><p class=MsoNormal align=center style='mso-margin-top-alt:0in;margin-right:28.35pt;margin-bottom:0in;margin-left:28.35pt;margin-bottom:.0001pt;text-align:center'><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'><img width=543 height=780 id="Picture_x0020_6" src="cid:image004.jpg@01CCCC94.F7282090"><o:p></o:p></span></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal align=center style='text-align:center'><span style='font-size:14.0pt;font-family:"Arial Black","sans-serif";color:black'><o:p> </o:p></span></p><p class=MsoNormal><o:p> </o:p></p></div></body></html>