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</o:shapelayout></xml><![endif]--></head><body lang=EN-US link=blue vlink=purple><div class=WordSection1><p class=titlechapter align=center style='text-align:center'><b><span style='font-size:14.0pt;color:#002060'>PhD Defense</span></b><b><span style='font-size:14.0pt'><o:p></o:p></span></b></p><p class=MsoNormal align=center style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:center;line-height:150%'><span style='font-size:14.0pt;line-height:150%;font-family:"Goudy Old Style","serif"'>Yi-Ju Wang</span><span style='color:#002060'>, </span><span style='font-size:14.0pt;line-height:150%;font-family:"Goudy Old Style","serif"'>Monday, July 18, 2011<span style='color:#002060'>, </span>10:00 AM<span style='color:#002060'><o:p></o:p></span></span></p><p class=MsoNormal align=center style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:center;line-height:150%'><span style='font-size:14.0pt;line-height:150%;font-family:"Goudy Old Style","serif"'>Chemical Engineering Conference Room<o:p></o:p></span></p><p class=MsoNormal align=center style='text-align:center;line-height:150%'><b><span style='font-size:14.0pt;line-height:150%;font-family:"Goudy Old Style","serif"'>Advisor:</span></b><span style='font-size:14.0pt;line-height:150%;font-family:"Goudy Old Style","serif"'> Dr. D. Litvinov<o:p></o:p></span></p><p class=MsoNormal align=center style='text-align:center;line-height:150%'><span style='font-size:11.0pt;line-height:150%;font-family:"Calibri","sans-serif";color:#002060'><o:p> </o:p></span></p><p class=MsoNormal align=center style='text-align:center;line-height:150%'><strong><span style='font-size:16.0pt;line-height:150%'>Development of Magnetoresistive Biosensors for Molecular Diagnostics<o:p></o:p></span></strong></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal style='text-align:justify;text-indent:24.0pt;line-height:200%;layout-grid-mode:char'>The giant magnetoresistance (GMR) phenomenon is manifested by a large change of the magnetic material’s resistance under the application of an external magnetic field. GMR sensors have been used extensively in magnetic hard-drive technology and have sensitivity sufficient to detect individual magnetic bits with sub-100nm dimensions.<o:p></o:p></p><p class=MsoNormal style='text-align:justify;text-indent:24.0pt;line-height:200%;layout-grid-mode:char'>Biomolecular sensing in medical diagnosis is a significant focus of recent research. Applying nano-magnetic device engineering to biosensing technology, we have developed a GMR sensor that is extremely sensitive to external magnetic fields and is capable of detecting individual magnetic biolabels. Some significant progress in the development of a tunneling magnetoresistance (TMR) biosensor was also achieved. Herein, the challenges of sensor design, fabrication, and surface functionalization are detailed.<o:p></o:p></p><p class=MsoNormal style='text-align:justify;text-indent:24.1pt;line-height:200%;layout-grid-mode:char'>Arrays of 300 nm-wide GMR sensors were patterned by electron beam lithography and photolithography on a silicon substrate. GMR multilayers (Co/Cu/Co) were deposited by UHV magnetron sputtering with the base pressure of 1.0 × 10<sup>-8</sup> torr. The sensors were conformally coated with 40 nm alumina thin films to electrically insulate the device and protect it from highly corrosive biological media. The sensing capability was confirmed with chemically immobilized magnetic particles on the sensor. Present work enables the production of a highly specific device for the detection of early stage cancer biomarkers, which is the long-term goal of our research.<o:p></o:p></p><p class=MsoNormal style='text-indent:24.0pt;line-height:115%;layout-grid-mode:char'><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p></div></body></html>