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</o:shapelayout></xml><![endif]--></head><body lang=EN-US link=blue vlink=purple><div class=WordSection1><p class=MsoNormal align=center style='text-align:center;text-autospace:none'><b><span style='font-size:16.0pt;font-family:"Tahoma","sans-serif"'>PhD Dissertation Announcement<o:p></o:p></span></b></p><p class=MsoNormal align=center style='text-align:center;text-autospace:none'><b><span style='font-size:14.0pt;font-family:"Tahoma","sans-serif"'>Laser Multi-Spectral Diffuse Scatter Confocal Microscopy<o:p></o:p></span></b></p><p class=MsoNormal align=center style='text-align:center;text-autospace:none'><b><span style='font-size:14.0pt;font-family:"Tahoma","sans-serif"'>Bian Hu<o:p></o:p></span></b></p><p class=MsoNormal style='text-autospace:none'><span style='font-family:"Arial","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-family:"Arial","sans-serif"'>Laser scanning confocal microscopy (LSCM) is widely used in biological science. However, in most applications, the laser is only used as a monochromatic excitation source for fluorescence. Many advantageous aspects of laser technology and the scattering property are not fully utilized. Also conventional LSCM measures only on-axis scattered light, neglecting the large angle scattering which contains information of target that would not be easily obtained by onaxis detection.<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-family:"Arial","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-family:"Arial","sans-serif"'>The objective of this work is to develop a novel optical microscopy technique based on two key features: laser multi-spectral confocal imaging and large angle azimuthal scatter diffuse<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-family:"Arial","sans-serif"'>imaging. Both features together give a combined spatial-spectral discrimination capability that can enhance contrast and spatial resolution not available from current optical microscopy. The<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-family:"Arial","sans-serif"'>goal is to contribute a new tool for biomedical, analytical, sensing and metrological applications. This work describes the principle of laser multi-spectral diffuse scatter confocal microscopy.<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-family:"Arial","sans-serif"'>Theoretical calculation and image simulation based on Finite Difference Time Domain (FDTD) are explored and provides theoretical basis and guide for experiments. Simulated confocal<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-family:"Arial","sans-serif"'>images and large angle scatter diffuse images of several targets are obtained and discussed. To the best of our knowledge, it is never done by any other researchers. The microscopic<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-family:"Arial","sans-serif"'>imaging system is based on a system architecture design configured similarly to an optical wireless network that allows multiple communication connections simultaneously among any<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-family:"Arial","sans-serif"'>number of transmitters and receivers. The whole imaging system includes control program, optical components layout etc is optimized. Confocal images and large angle scatter diffuse<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-family:"Arial","sans-serif"'>images are obtained and demonstrate high dynamic range and high image contrast of the imaging system. The experimental results are promising with capability to uncover and interpret<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-family:"Arial","sans-serif"'>features that are not easily achieved by conventional confocal microscopic method. It proves that Laser Multi-Spectral Diffuse Scatter Confocal Microscopy is novel technology that can<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-family:"Arial","sans-serif"'>obtain full information about targets and widely used for biomedical, analytical, sensing and metrological applications.<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><b><span style='font-family:"Tahoma","sans-serif"'><o:p> </o:p></span></b></p><p class=MsoNormal style='text-autospace:none'><b><span style='font-family:"Tahoma","sans-serif"'>Committee Chair: </span></b><b><span style='font-family:"Arial","sans-serif"'>Dr.Han Le </span></b><b><span style='font-family:"Tahoma","sans-serif"'>Place: E319-D3 Date: Nov 22, 2010 Time: 3:00 pm – 5:00 pm<o:p></o:p></span></b></p><p class=MsoNormal style='text-autospace:none'><span style='font-family:"Tahoma","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-family:"Tahoma","sans-serif"'>Committee Members: </span><span style='font-family:"Arial","sans-serif"'>Dr. Ji Chen, Dr. Jiming Bao, Dr. Len Trombetta, Dr. Loannis A Kakadiaris</span><o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p></div></body></html>