[CCoE Notice] SABIC Seminar Series 1/31

[Knudsen, Rachel W]

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[FAST, Smart Therapeutics]
[Anushree Chatterjee, Ph.D. Assistant Professor  University of Colorado Boulder  Friday, January 31, 2020, 10:30 am Engineering 2, room W122]
[The rapid rise of multidrug-resistant (MDR) superbugs and the declining antibiotic pipeline are serious challenges to global health. Rational design of therapeutics can accelerate development of effective therapies against MDR bacteria. In this talk, I will describe multi-pronged systems, synthetic biology, and nano-biotechnology based approaches being devised in our lab to rationally engineer therapeutics that can overcome antimicrobial resistance. We have developed Synthetic biology-based approach dubbed "Controlled Hindrance of Adaptation of OrganismS" or "CHAOS" to slow the evolution of antibiotic resistance by interfering with the processes involved in adaptive resistance. To translate our findings into the clinical setting, we have engineered antisense therapeutics that can block translation or increase transcription of any desired gene in a species-specific manner for targeted inhibition. Using this approach we have built a Facile Accelerated Specific Therapeutic (FAST) platform for the accelerated therapeutics in less than a week.  Finally, I will also present a nano-biotechnology based approach involving development of a unique semiconductor material based quantum dot-antibiotic (QD ABx) which, when activated by stimuli, release reactive oxygen species to eliminate a broad range of MDR bacterial clinical isolates. The CHAOS, FAST and QD Abx platforms and inter-disciplinary approaches presented in this talk offer novel methods for rationally engineering new therapeutics to combat disease challenges.     Dr. Anushree Chatterjee is an Assistant Professor of Chemical and Biological Engineering at University of Colorado Boulder. Prior to joining UC Boulder, she was a postdoctoral research fellow at the Theoretical Biology and Biophysics group at Los Alamos National Laboratory studying gene regulation of hepatitis C virus. She completed her Ph.D. in Chemical engineering at the University of Minnesota on understanding molecular mechanisms of antibiotic resistance transfer in clinical superbugs. She completed her Bachelor and Master of Technology in Chemical Engineering from Indian Institute of Technology Delhi. The overarching goal of her research is to develop strategies for rationally engineering next-generation smart antimicrobials that can eliminate multi-drug resistant superbugs, with the ultimate goal of creating therapies that can evade evolution of drug-resistance in microbes.]
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