[CCoE Notice] BME Seminar Series Presents: Biomedical Optoacoustic Imaging: 25 Years of Development from First Ideas to Clinical Trials

[Grayson, Audrey A]

University of Houston - Biomedical Engineering Seminar

Friday, Oct. 19, 2018, Noon, Rm 205 SEC

BIOMEDICAL OPTOACOUSTIC IMAGING:

25 YEARS OF DEVELOPMENT FROM FIRST IDEAS TO CLINICAL TRIALS

[cid:886d4f63-fccf-47a7-811c-c027aa7faa00]

Alexander A. Oraevsky, Ph.D.

ABSTRACT

Optoacoustic imaging established its place in the main stream medicine due to its capability to provide physician not only with anatomical, but also functional and molecular information. This lecture will discuss development of the field of optoacoustic imaging from pioneering works that set the basic principles of the technology to the first in vivo images, to the most recent validation of clinically viable systems, and finally our vision of the future medical imaging modalities and their applications in the main stream medicine and surgery. Since clinically viable applications require visualization of tissues at the depth of at least 1 cm, we are most interested in the optoacoustic technologies that enable high resolution imaging in the depth of tissue using optical contrast.



Discoveries that made optoacoustic imaging the most rapidly developing biomedical imaging technology in the 21st century are that (1) laser pulses may be effectively used to produce ultrawide-band acoustic pressure (ultrasonic waves) in biological tissues, which carry its main energy in the lower frequency range and, thus, propagate in tissues with minimal attenuation, (3) 2D and 3D images of the absorbed optical energy can be reconstructed with high resolution under the illumination condition of pressure confinement in the course of the optical energy deposition in a voxel to be resolved.



2D and 3D system designs will be discussed along with their advantages and limitations for specific biomedical applications.  The most important results obtained by our group in the past 25 years will be presented, including in vivo preclinical and clinical functional-anatomical maps of vasculature and tumors. Diagnostic imaging of breast cancer motivated development of the first optoacoustic imaging systems in the early years, and today it has become the first commercially available clinical application. Many more clinical applications of the optoacoustic imaging will be commercialized in the near future. The technological developments that will transform optoacoustic imaging systems into compact and robust clinical modalities are the high power diode lasers and the supersensitive ultrawide-band ultrasonic detectors.



BIOSKETCH

Dr. Alexander A. Oraevsky has over 25 years of experience managing research and development laboratories in academia and small businesses. He is a pioneer in the field of biomedical opto-acoustic imaging and sensing.  Alexander obtained a doctorate in laser spectroscopy and laser biophysics from the USSR Academy of Sciences in 1986. In 1992, as Whitaker Fellow, he joined the faculty at Rice University.  Prior to his leadership position at TomoWave Laboratories, he was a Chief Scientific Officer at Seno Medical Instruments, Vice President of R&D at Fairway Medical Technologies, Director of the Optoacoustic Imaging and Spectroscopy Laboratory at the University of Texas Medical Branch in Galveston and an Assistant Professor at the Department of Ophthalmology and Visual Sciences.  Presently he holds a Santander Chair of Excellence in Physics at the University Carlos III of Madrid, Distinguished Professor of Medical Imaging at Guangzhou Medical University, an adjunct Professor of Biomedical Engineering at the University of Houston.  Alexander is the holder of 21 patents, has published ten book chapters and over 200 scientific papers that received over 11,000 citations.  Dr. Oraevsky is the recipient of multiple research awards advancing biomedical applications of the optoacoustic imaging sensing and monitoring, including Berthold Leibinger Innovations Prize 2014 and John Smith Award from the International Photoacoustic and Photothermal Association.  Research of Dr. Oraevsky was sponsored with $19M in grants from NIH, DOD and other foundations.  He is the founder and Chair of the largest conference in the field of laser optoacoustic ultrasonic imaging under the auspices of SPIE. He serves on multiple review and expert panels including NIH, DoD, EU Commission, Canada National Research Council and others.

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