[CCoE Notice] You're Invited to the 2018 Amundson Lecture!

Thu Jan 25 13:10:26 CST 2018

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[University of Houston Cullen College of Engineering - Department of Chemical and Biomolecular Engineering]<http://www.chee.uh.edu/>

[The 2018 Amundson Lecture]

University of Houston
Cullen College of Engineering
Engineering Lecture Hall L2D2
4726 Calhoun Road
Houston, TX 77204

Refreshments served at 4:00 pm
Lecture from 4:30 pm – 5:30 pm

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Fighting Cancer with Nanoparticle Medicines:
How Size Can Matter

By

Mark E. Davis
Chemical Engineering
California Institute of Technology
Pasadena, CA 91125

Abstract

For centuries, cancer has been one of the most devastating diseases. Papyrus writings from 1600-1500 BC describe cancer and attempts at its treatment. Today, the molecular basis of cancer is being unraveled, and therapeutics are being developed to take advantage of this increasing knowledge. One new class of experimental therapeutics involves the use of nanoparticles, where the control of size dramatically determines performance. Given the long history of difficulties in developing cancer therapies, are nanoparticle medicines (nanomedicines) worth the hype? I discuss the current understandings of why engineered nanoparticle medicines (that are highly multifunctional chemical systems) have the potential to provide “game changing” ways to treat cancer. I then illustrate the various features and potentials of nanoparticle medicines using two different nanoparticles that we have translated from laboratory curiosities into experimental therapeutics in human clinical trials. I conclude with our new approach to bring therapy safely into the brain using nanoparticles.

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Mark E. Davis is the Warren and Katharine Schlinger Professor of Chemical Engineering at the California Institute of Technology and a member of the Comprehensive Cancer Center at the City of Hope and the Jonsson Comprehensive Cancer Center at UCLA. He has over 450 scientific publications, two textbooks and over 90 US patents. Professor Davis is a founding editor of CaTTech and has been an associate editor of Chemistry of Materials and the AIChE Journal. He is the recipient of numerous awards including the Colburn and Professional Progress Awards from the AIChE and the Somorjai, Ipatieff, Langmuir, Murphree and Gaden Prizes from the ACS. Professor Davis was the first engineer to win the NSF Alan T. Waterman Award. He was elected in the National Academy of Engineering in 1997, the National Academy of Sciences in 2006 and the National Academy of Medicine in 2011. In 2014, he received the Prince of Asturias Award for Technical and Scientific Research from the King of Spain, and in 2015, he was elected into the National Academy of Inventors. Professor Davis’ research efforts involve materials synthesis in two general areas; namely, zeolites and other solids that can be used for molecular recognition and catalysis, and polymers for the delivery of a broad range of therapeutics. He is the founder of Insert Therapeutics Inc., Calando Pharmaceuticals, Inc. a company that created the first RNAi therapeutic to reach the clinic for treating cancer, and Avidity Biosciences. He is/has been a member of the scientific advisory boards of Symyx (Nasdaq: SMMX), Alnylam (Nasdaq: ALNY) and Intellia Therapeutics (Nasdaq: NTLA). Professor Davis has achieved All American Status for Masters Track and Field in the 400, 200 and 100 Meter Dashes. In 2011, he won the 400 Meter Dash for men of age 55-59 at the Masters World Championship.

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About Neal R. Amundson

[.]     [Amundson]

Neal R. Amundson, affectionately known as “The Chief”, is widely regarded as the most prominent educator in the modern age of Chemical Engineering. Neal completed his illustrious career as Cullen Professor of Chemical Engineering and Mathematics. Neal passed away in January of 2011.

Dr. Amundson, a Minnesota native, was educated at the University of Minnesota, earning a BS ChE (1937), an MS ChE (1941), and a PhD in Mathematics (1945). He taught in the Mathematics Department until 1947. He joined the University of Minnesota’s Chemical Engineering Department, where he served as Chairman from 1947 until 1977. He became Regents’ Professor in 1967. Under his leadership, the school’s Chemical Engineering Department attained the preeminent position that it holds today. Neal joined the University of Houston in 1977. He served as UH Provost from 1987 to 1989.

Neal is remembered as an exceptionally prolific, innovative and influential ChE researcher. His contributions included modeling and analysis of chemical reactors, separation systems, polymerization, and coal combustion. He had a profound, pioneering impact on the education of chemical engineers, changing the teaching of the field from a qualitative, descriptive approach to precise scientific methodologies. He was for several decades an intellectual leader of the Chemical Engineering community, and he chaired the NRC committee that wrote the report on “Frontiers in Chemical Engineering.”

Neal’s contributions have been recognized through conferral of numerous professional awards by the AIChE, ACS, ISCRE, and ASEE. He was elected to the NAE, NAS, and the American Academy of Arts & Sciences. He received the NAE Founders’ Award, and honorary doctorates from the Universities of Minnesota, Notre Dame, Pennsylvania, Guadalajara, and Northwestern University. He received the Farfel Award, the highest faculty honor given by the University of Houston.

The building that houses the Department of Chemical Engineering & Materials Science at the University of Minnesota was named “Amundson Hall” in 1979. ISCRE has named its major award the Amundson Award.

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Previous Lecturers:

2000: Andreas Acrivos (Stanford University)

2002: John Seinfeld (California Institute of Technology)

2003: Roy Jackson (Princeton University)

2005: L.E. “Skip” Scriven (University of Minnesota)

2008: Haren Gandhi (Ford Motor Company)
and Michael Economides (University of Houston)

2010: Sankaran Sundaresan (Princeton University)

2012: Lee Raymond (ExxonMobil)

2015: Robert S. Langer (Massachusetts Institute of Technology)

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