[CCoE Notice] BME Seminar Series Presents: Photonic and Acoustic Tools for Imaging, Navigation and Activation of Remote Controlled Theranostic Carriers

[Grayson, Audrey A]

University of Houston - Biomedical Engineering Seminar

Friday, Dec. 7, 2018 Noon, Rm 201 SEC



PHOTONIC AND ACOUSTIC TOOLS FOR IMAGING, NAVIGATION AND ACTIVATION OF REMOTE CONTROLLED THERANOSTIC CARRIERS



[cid:1de71c99-986b-4824-9d49-b636f1a80ebf]


D.A. Gorin, Ph.D.

Skolkovo Institute of Science and Technology, Skoltech, Moscow, Russia

Saratov State University, SGU, Saratov, Russia



ABSTRACT

The photonic and acoustic tools that can be used for in vivo navigation, visualization and activation of new type of multifunctional carriers will be presented. These carriers will combine ability to deploy drug in controllable manner with physical triggering [1] and sensing of important biological markers [2]. Physical targeting of carriers was realized by gradient of magnetic field [1], optical tweezers approach [3].  Acoustic field has a good perspectives for same purpose [4]. The carrier sensitivity to external influences as laser irradiation, ultrasound treatment [5] can be changed by variation of volume fraction and chemical composition of inorganic nanoparticles in the nanocomposite carrier shells [1-3, 5-7]. Same approach is applied for drug delivery carriers and biosensors imaging by MRI [6], OCT [7] and photoacoustics [8] using magnetite and gold nanoparticles as contrast agents, respectively. Combination of photonic and acoustic tools with multifunctional carriers has a good perspective for application in biomedicine for diagnostic and therapy.

1. Voronin D.V. et al., ACS App. Mat. & Inter., 2017, 9, 6885

2. Stetciura I.Y. et al., Cur.Opin.Pharm. 2014, 18, 149

3. Stetciura I. Y. et al., Analyst, 2015, 140, 4981

4. Ochiai Y.  et al., PLoS ONE 9(5), 2014, e97590. doi:10.1371/ journal.pone.0097590

5. Korolovych V.F. et al., PCCP, 2016, 18, 2389

6. German S.V. et al., PCCP, 2016, 18, 32238

7.  Genina E.A. et al., Bio.Opt.Exp., 2016, 7, 2082.

8. Yashchenok A.M.et al., J. Biophoton., 2016, 8, 792

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