[CCoE Notice] BME/ME Seminar: Elastography: Principles and Applications for Characterization of Tissue Mechanical Properties

[Grayson, Audrey A]

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Departments of Biomedical and Mechanical Engineering

Seminar

Elastography: principles and applications for characterization of tissue mechanical properties
Friday, October 7, 2016
SEC 204: 12-1PM
Speaker: Dr. Salavat Aglyamov

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Salavat Aglyamov, Ph.D.
Center for Emerging Imaging Technologies
Department of Biomedical Engineering
University of Texas at Austin

Abstract: Elastography is a general name for a group of diagnostic methods capable of remote evaluation of tissue mechanical properties. Biochemical, molecular, cellular, and functional (i.e., microscopic) changes in biological tissues leading to pathologies often result in mac-roscopic changes in tissue properties, such as tissue elasticity. Areas of applications of elasticity imaging in medical diagnostics and treatment monitoring are steadily expanding. Elastography has shown great promise for many biomedical applications including the diagnosis of breast and prostate cancer, heart diseases, and atherosclerotic plaques, as well as the estimation of muscle condition, the staging of deep vein thrombosis etc. The biomechanical characteristics of ocular tissues have a profound influence on the health, structural integrity, and normal function of the eye. Such conditions as presbyopia, corneal ectasia and keratoconus correlate with stiffness of the tissue. We have developed noninvasive approaches to measure elastic properties of the ocular tissues using acoustic radiation force and air puff stimulation. The displacements in tissue are measured using high frequency ultrasound and optical coherence tomography, and mechanical properties are evaluated based on developed mathematical model of the dynamic deformation of the viscoelastic incompressible medium. This approach has been successfully tested in ex-vivo and animal studies to monitor the changes in mechanical properties during corneal cross-linking treatment and aging. We demonstrated the capability to measure spatial variations in mechanical properties for both normal and treated corneas, young and mature crystalline lenses and vitreous humors.

Bio: Dr. Salavat Aglyamov received his B.S. and M.S. degrees in Applied Mathematics from Moscow State University, Moscow, Russia. He received the Ph.D. degree in Biophysics from the Institute of Theoretical and Experimental Biophysics, Pushchino, Moscow region, Russia, and following postdoctoral research at the University of Michigan, Ann Arbor. Salavat Aglyamov is currently a research scientist in the Center for Emerging Imaging Technologies, Department of Biomedical Engineering at the University of Texas at Austin. His research interests are in the areas of elastography, tissue biomechanics, biomedical imaging, ultrasound, OCT, photoacoustics and applied mathematics. A major focus of Dr. Aglyamov’s research is to develop noninvasive methods for the diagnosis of soft tissue pathologies based on measuring tissue mechanical properties.
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