[CCoE Notice] Seminar: Nano- and Microfabricated Hydrogels for Regenerative Engineering

[Grayson, Audrey A]

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Seminar
Nano- and Microfabricated Hydrogels for Regenerative Engineering
Friday, April 22, 2016
SEC 204: 12:00 PM – 1:00 PM
Speaker: Dr. Ali Khademhosseini
Professor
Department of Medicine, Brigham and Women’s Hospital,
Harvard Medical School, Cambridge, MA
Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA

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Abstract: Engineered materials that integrate advances in polymer chemistry, nanotechnology, and biological sciences have the potential to create powerful medical therapies. Our group aims to engineer tissue regenerative therapies using water-containing polymer networks, called hydrogels, that can regulate cell behavior. Specifically, we have developed photocrosslinkable hybrid hydrogels that combine natural biomolecules with nanoparticles to regulate the chemical, biological, mechanical and electrical properties of gels.  These functional scaffolds induce the differentiation of stem cells to desired cell types and direct the formation of vascularized heart or bone tissues. Since tissue function is highly dependent on architecture, we have also used microfabrication methods, such as microfluidics, photolithography, bioprinting, and molding, to regulate the architecture of these materials. We have employed these strategies to generate miniaturized tissues.  To create tissue complexity, we have also developed directed assembly techniques to compile small tissue modules into larger constructs. It is anticipated that such approaches will lead to the development of next-generation regenerative therapeutics and biomedical devices.

Bio: Ali Khademhosseini is a Professor at Harvard-MIT's Division of Health Sciences and Technology, Wyss Institute of Biologically Inspired Engineering, Brigham and Women's Hospital and Harvard Medical School. His laboratory is developing bioinspired approaches for generating tissue-like structures as well as fabricating biomaterials for various medicine applications. He has been cited over 23,000 times and has an H-index of 80. Dr. Khademhosseini has received over 40 major national and international awards and Technology Review Magazine named him as one of the "Top Young Innovators" (TR35). He is a fellow of AAAS, AIMBE, RSC, and FBSE. Currently, he serves on the editorial board of numerous journals and is an Associate Editor for ACS Nano. He received his Ph.D. in bioengineering from MIT (2005), and MASc (2001) and BASc (1999) degrees from University of Toronto both in chemical engineering.

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