[CCoE Notice] ***Seminar*** - Monday Jan. 9 at noon - multiphase approach for tumor growth modeling

[Reagan Herman]

Seminar

Monday, January 9th, 2012

12:00 PM – 1:00 PM

Engineering Building 2 Room E132 – Materials Lab

 

A multiphase porous media mechanics approach for tumor growth modeling

 

Bernhard A. Schrefler

 

Professor at the University of Padua and Senior Affiliate Member of The
Methodist Hospital Research Institute, Department of Nanomedicine

 

Multiphase porous media mechanics is used to model tumor growth.  The
governing equations are obtained by means of the Thermodynamically
Constrained Averaging Theory (TCAT), rather than the less complete theory of
mixture. This is a framework recently established for the analysis of
continua and porous media that is consistent over multiple scales. The
multiphase porous media mechanics approach takes into account the
interaction of more phases than legacy tumor growth models, which usually
neglect the evolution of the interstitial fluid pressure. The tumor is first
modeled as a multiphase system composed of an extracellular matrix, healthy
cells, tumor cells which may become necrotic depending on the nutrient level
and the pressure, and an interstitial fluid which transports nutrients. The
governing equations  are solved within a Finite Element framework for
predicting the growth rate of the tumor mass and its individual components,
as a function of the i) initial tumor-to-healthy cell density ratio; ii)
nutrient concentration; and iii) mechanical strains. This seminar will
discuss preliminary results of this model and of significant subsets of it.
Application of this model to patient specific data will allow for
patient-specific predictions of the optimal concentration of therapeutic
agents.

 

Professor Bernhard Schrefler

Short Biography

 

Professor Bernhard A. Schrefler received his   Ph.D. in 1984 and D.Sc. in
1992  from the University of Wales, Swansea.  He is on the Faculty of
Engineering of the University of Padua since 1970, was promoted to Professor
of Structural Design in 1980 and is Professor of Structural Mechanics from
1989 on. Dr. Schrefler is also a Senior Affiliate Member of The Methodist
Hospital Research Institute in Houston, where he is affiliated with the
Department of Nanomedicine. He was visiting Professor at the Ecole Centrale
of Nantes, the University of Texas, Austin, the Ecole Polytechnique Federale
of Lausanne, the Chuo University of Tokyo, the Ecole Normale Supérieure in
Cachan, the Lodz University of Technology, at CNAM (Conservatoire National
des Arts et Metiers), Paris, and Dalian University of Technology. Since 2001
he is secretary general of the International Centre of Mechanical Sciences
(CISM) in Udine.

His current research focuses on tumor growth modeling and transport of
nanoparticles in diseased microvasculature. Other research interests deal
with multiphase porous media mechanics with applications to bioengineering
and environmental engineering, multiphase models for young concrete and
concrete at high temperatures with application to tunnel fires, leaching and
Alkali-Aggregate reaction, use of Artificial Neural Networks as constitutive
models, for parameter identification and optimization, and with design of
superconducting coils for controlled nuclear fusion technology.

Professor Schrefler is co-author in more than 430 scientific publications
and co-author/editor of 29 books. He is regional editor of Mechanics
Research Communications and serves on the editorial board of 19 Journals. 

 

 



 

 

 

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