[CCoE Notice] PhD Dissertation Defense Announcement

[Khator, Suresh]

PhD Dissertation Defense Announcement


DEVELOPMENT OF PHASE STABILIZED SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY FOR BIOMEDICAL IMAGING AND ELASTOGRAPHY

Ravi Kiran Manapuram

April 19, 2012, 1: 15 PM, N202-Mechanical Engineering Large conference
Committee: Dr. Kirill Larin (Chair), Dr. Pradeep Sharma, Dr. Lowell Wood, Dr. Ralph Metcalfe, Dr. Matthew Franchek

This dissertation describes the development and several applications of a system capable of noninvasive 3D imaging of tissues with near cellular resolution. This system is based on Optical Coherence Tomography (OCT) technique and can provide both imaging and phase sensitive measurements. The key characteristics of the developed system include:  axial resolution of 8 µm, lateral resolution of 15 μm, imaging depth of 9 mm, signal-to-noise ratio of 101 dB and phase stability of 9 mrad (which translates to 1.9 nm of optical path length sensitivity).  The system was applied to several biomedical applications such as detection of microbubbles in tissues and blood and assessing mechanical wave propagation under both in vitro and in vivo conditions. The results demonstrate capability of this technique to detect submicron air bubbles as well as measure amplitude (~ 30 nm) and speed of mechanical waves propagating on tissue surfaces. The high sensitivity of the system was exploited to measure microbubbles in mice tail vein and mechanical wave propagation in mice cornea as a function of age in vivo. To the best of our knowledge, this is the first time OCT is applied to assess microbubbles and mechanical wave parameters in ocular tissues in vivo. The results described in this dissertation provide necessary theoretical and experimental foundation for developing devices for future clinical applications.




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