[CCoE Notice] UH Chemical & Biomolecular Engineering Weekly Seminar Series for 2:00 PM - Friday, March 4, 2011

[Lewis, Lindsay R]

***** Seminar *****
DEPARTMENT OF CHEMICAL AND BIOMOLECULAR ENGINEERING
University of Houston
2:00 P.M. - Friday, March 4, 2011
L2D2


Mass Transfer in Drug Delivery and
Cellular Biological Media:
Impact of the Pioneering Contributions of
Alkiviades C. Payatakes to an Emerging Field

Nicholas A Peppas, ScD

Fletcher Stuckey Pratt Chair in Engineering
Professor of Chemical Engineering, Biomedical Engineering and Pharmacy
Chair, Department of Biomedical Engineering
Director, Center on Biomaterials, Drug Delivery,
Bionanotechnology and Molecular Recognition

Abstract

During the early days of drug delivery studies, the field was considered outside of the main scope of chemical engineering. Yet, major successes in health care and disease treatment through careful engineering design of advanced drug delivery systems led to maturity of the field, where biomedical transport phenomena and biopolymer development merged to create a generation of general and targeted drug delivery systems for the treatment of a wide range of diseases. These days, successful targeted delivery systems are designed to allow delivery of therapeutic or diagnostic agents to a preferential site. Alkis Payatakes (1945-2009) of the Universities of Houston and Patras was an inspirational leader and pioneer in the field of transport in porous media. His models were applied not only to classical two-phase flow, immiscible microdisplacement of non-wetting fluids and enhanced oil recovery but also to mass transport in cellular biological media. Here, we present the evolution of such models and discuss their impact in the design of the new generation of protein drug delivery systems for the treatment of Type 1 diabetes, osteoporosis and multiple sclerosis. In addition, we highlight some of the recent work on targeted delivery systems and focus on in vivo performance, localization, and incorporation of diagnostic and therapeutic agents in targeted delivery systems.


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