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<p class="xmsonormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif;color:#1F497D"> </span><span style="font-size:10.5pt;font-family:"Arial",sans-serif;color:#2F5597">***** Special
<span class="xxxxxxxmark4adj242bs">Seminar</span> *****</span><o:p></o:p></p>
<p class="xmsonormal"> <o:p></o:p></p>
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<p class="xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxmsonormal"><b><span style="font-size:16.0pt;font-family:"Times New Roman",serif">William A. Brookshire Department of Chemical and Biomolecular Engineering</span></b><o:p></o:p></p>
<p class="xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxmsonormal">Presents<o:p></o:p></p>
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<o:p></o:p></p>
<p class="xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxmsonormal"><span style="font-size:20.0pt;font-family:"Times New Roman",serif">What Do We Know About Bacterial Persisters?</span><o:p></o:p></p>
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<b><span style="font-size:14.0pt;font-family:"Times New Roman",serif"> </span></b><o:p></o:p></p>
<p class="xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxmsonormal"><b><span style="font-size:14.0pt;background:yellow">Tuesday April 19, 10:00am</span></b><o:p></o:p></p>
<p class="xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxmsonormal"><b><span style="font-size:14.0pt;background:yellow">Science Building, Room 105</span></b><o:p></o:p></p>
<p class="xmsonormal"><span class="xxxxxxxxxa0"><span style="font-size:14.0pt">Or virtually at</span></span><span class="xxxxxxxxxa0"><b><span style="font-size:20.0pt">
</span></b></span><a href="https://urldefense.com/v3/__https:/uh-edu-cougarnet.zoom.us/j/94690883059__;!!LkSTlj0I!Hu4C-8zSTt7claaVg7zzELLTRsUsPna1vXt4PTtlMiJG3xZf0uCfOGsH8yjZUO4n-Ff8LjOTsRFV3x5KgMVvxMSdvYU$">https://uh-edu-cougarnet.zoom.us/j/94690883059</a><o:p></o:p></p>
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<p class="xmsonormal"><span class="xxxxxxxxxa4"><b><span style="font-size:18.0pt;font-family:"Times New Roman",serif;color:#174E86"> </span></b></span><span class="xxxxxxxxxa4"><b><span style="font-size:18.0pt;font-family:"Times New Roman",serif">
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<p class="xmsonormal"><span class="xxxxxxxxxa4"><b> </b></span><o:p></o:p></p>
<p class="xmsonormal"><strong><span style="font-size:16.0pt;font-family:"Calibri",sans-serif">Mehmet Orman, Ph.D.</span></strong><span class="xxxxxxxxxa4"><b><span style="font-size:16.0pt;color:#174E86">
</span></b></span><span style="font-size:16.0pt;color:#174E86"> </span><o:p></o:p></p>
<p class="xmsonormal"><span style="font-size:16.0pt">Assistant Professor</span><o:p></o:p></p>
<p class="xmsonormal"><span style="font-size:16.0pt">University of Houston</span><o:p></o:p></p>
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<p style="text-align:justify;background:white"><b><span style="color:#0C64C0">Abstract</span></b><span style="color:#0C64C0">:</span><span style="font-size:12.0pt;font-family:"Times New Roman",serif">
</span><span style="font-family:"Times New Roman",serif;color:#0C64C0"> <b><br>
</b></span><span style="font-family:"Times New Roman",serif">Our bodies have trillions of more microbial cells than human cells. Although most of these microorganisms are symbiotic and harmless, and play crucial roles in our health, some of them are pathogenic
and can survive asymptomatically for a long time without growing. Due to their transient non-growing state, these pathogens can regain the ability to initiate cell growth (a phenotypic switch that is poorly understood) and establish cell populations that can
cause diseases. My research group aims to characterize the microbial phenotypes that exist in a transient, growth-inhibited state. These cells, which are also called persisters, can survive high concentrations of antibiotics due to their growth-inhibited state.
Antibiotic failure is a growing concern worldwide, and persister cells significantly contribute to this problem, as they can promote the emergence of antibiotic-resistant mutants and facilitate the recurrence of microbial infections. A deeper understanding
of the molecular make-up of persister cells will facilitate the development of novel therapeutic strategies. Therefore, a major goal of my research is to study their physiology: the metabolite, RNA, and protein content that allow them to tolerate extraordinary
concentrations of drugs.</span><o:p></o:p></p>
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<p class="xxxxxxxxmsonormal" style="margin-bottom:12.0pt;text-align:justify"> <o:p></o:p></p>
<p class="xxxxxxxxmsonormal" style="text-align:justify"><b><span style="font-family:"Times New Roman",serif;color:#0C64C0">Bio</span></b><span style="font-family:"Times New Roman",serif;color:#0C64C0">:</span><o:p></o:p></p>
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<p class="xmsonormal" style="text-align:justify"><span style="font-family:"Times New Roman",serif">Dr. Orman has obtained his Ph.D. in Chemical Engineering from Rutgers University-New Brunswick and completed his post-doctoral studies at Princeton University
and Memorial Sloan Kettering Cancer Center. He is currently an assistant professor at the Chemical and Biomolecular Engineering Department at the University of Houston. Dr. Orman has made significant contributions to the field of bacterial persisters that
present a treatment challenge. He received the prestigious NIAID Career Transition Award (K22) and an R01 grant from the National Institutes of Health, an impressive accomplishment for a junior faculty member. Dr. Orman is also the recipient of NSF CAREER
Award; he has proposed a compelling early career plan that integrates research and educational components that are well aligned with university initiatives.
</span><o:p></o:p></p>
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