[ChBE-Grad] ChBE Seminar this Friday

[Solano, Nicolette]

UH ChBE Dept. Seminar
10:30am-11:30am, Friday, January 20, 2017
Rm L2D2
Engineering Functional Biomaterials: From Stem Cell Morphogenesis to Targeted Drug Delivery
Donny Hanjaya-Putra, PhD
Wyss Institute for Biologically Inspired Engineering
Harvard Medical School, Boston MA




ABSTRACT:
 Functional biomaterials can be engineered with tunable physical and chemical properties to a range of applications in biotechnology, from bio-responsive hydrogels to targeted drug conjugate. The first part of my talk will focus on work completed during my graduate work aimed at development of biomaterials to control vascular morphogenesis from stem cells. The success of tissue engineering has been hindered by functional vascular networks to support the engineered-organs. To overcome this limitation, we developed synthetic polysaccharide hydrogels that provide spatial and temporal control for vascular morphogenesis. Consequently, generating these vascular beds from stem cells and synthetic polymer was proven to be useful in aiding the transplantation of tissue-engineered constructs into a range of vascular disorders. The second part of my talk will focus on our on-going efforts at developing strategies to limit thrombosis and inflammation in the context of venous thrombosis and stem cell transplantation. Despite recent advances in anticoagulation therapy, the rate of bleeding complication remains high, especially for patients with multiple risk factors. To address these challenges, we developed a fusion of protein and single-chain-antibody that combines potent anti-coagulation with platelet targeting. Using this unique approach, we inhibited thrombosis without altering systemic coagulation profiles. Collectively, these two examples illustrate that functional biomaterials are powerful and versatile platforms for various applications in biomedicine.














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